Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2721-2724.doi: 10.3969/j.issn.1673-8225.2011.15.015

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Ischemic area changes following moderate training in rat models of ischemic heart

Li Dan1,2,3, Zhao Bao-yin1,2,3, Li Lei1,2,3, Zhong Jia-yong4, Zhang Zhi-peng4, Chen Yi-lin1,2,3, Shen Xiao-tao1,2,3,4, Li Yan-mei1,2,3, Yu Yan-hong1,5, Cai Dong-qing1,2,3   

  1. 1Key Laboratory for Regenerative Medicine, Ministry of Education, 2Joint Laboratory for Regenerative Medicine, the Chinese University of Hong Kong-Jinan University, 3The International Base of Collaboration for Science & Technology (Jinan University), the Ministry of Science and Technology & Guangdong Province Scinece and Technology Bureau, 4Department of Biomedical Engineering, 5Institute of Reproductive Immunology, College of Life Science and Technology, Jinan University, Guangzhou  510632, Guangdong Province, China
  • Received:2011-01-04 Revised:2011-03-05 Online:2011-04-09 Published:2013-11-06
  • Contact: Cai Dong-qing, Professor, Doctoral supervisor, 1Key Laboratory for Regenerative Medicine, Ministry of Education, 2Joint Laboratory for Regenerative Medicine, the Chinese University of Hong Kong-Jinan University, 3The International Base of Collaboration for Science & Technology (Jinan University), the Ministry of Science and Technology & Guangdong Province Scinece and Technology Bureau, Jinan University, Guangzhou 510632, Guangdong Province, China tdongbme@jnu.edu.cn
  • About author:Li Dan★, Studying for master’s degree, 1Key Laboratory for Regenerative Medicine, Ministry of Education, 2Joint Laboratory for Regenerative Medicine, the Chinese University of Hong Kong-Jinan University, 3The International Base of Collaboration for Science & Technology (Jinan University), The Ministry of Science and Technology & Guangdong Province Scinece and Technology Bureau, Jinan University, Guangzhou 510632, Guangdong Province, China quanliyifu66@163.com
  • Supported by:

    the National 863 Program of China, No. 2007AA02Z105*; the National Natural Science Foundation of China, No. 30770886*, 30570369*, 30340038*, 30973158*; the Key Program of Guangdong Natural Science Foundation, No. 04105826*; Guangdong Grant for Science and Technology Development, No. 2004B30601007*; International Collaborated Grant of Guangdong, No. 2009B050900007*; the Fundamental Research Funds for the Central Universities, No. 21609408*

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Abstract:

BACKGROUND: It is still controversy regarding to whether moderate training, treated in acute period of myocardial infarction (MI), plays a benefit role in regeneration of myocardial infarction.
OBJECTIVE: To investigate the effect of moderate training on infarct areas after myocardial infarction.
METHODS: Forty-eight Sprague-Dawley (SD) rats were randomly divided into four experimental groups (male and female trained group and female and male control group), In 24 hours after left anterior descending coronary artery (LAD) ligation, the trained groups were introduced to treadmill training (20 m/min, 0% grade, 30 min/d) for 12 days, while the control groups were fed normally after LAD-ligation. The infarcted size and the geometry of left ventricle (LV) of the trained and control groups were analyzed respectively under the Masson’s Trichrome staining in two-week of MI.
RESULTS AND CONCLUSION: It was found that the mortality of trained group was similar to the control group (trained group: 22% vs. control group: 20%). The infarction size of trained group was less than that of control group in two weeks after MI. The difference had statistics significance (P < 0.05). In addition, it was found that the wall thickness of border zone in left ventricle of trained group was longer than control (P < 0.05); while the thickness of infarcted myocardium in LV was greater than that of the control group. All results demonstrated that the moderate-intensity treadmill training treated in acute period of MI did not significantly reduce the survival rate of rats. On the contrary, it was able to reduce the infarcted size of MI. In addition, the moderate treadmill training was able to improve the reconstruction of LV geometry after MI. The effect has no difference on different genders.

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