Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (23): 4354-4358.doi: 10.3969/j.issn.1673-8225.2012.23.033

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Application of bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injury

Wang Ge1, Wu Dong-cheng2   

  1. 1Wuhan University, Wuhan 430071, Hubei Province, China;
    2Department of Biochemistry, Wuhan University, Wuhan Hongqiao Brain Hospital, Wuhan 430071, Hubei Province, China
  • Received:2011-11-08 Revised:2011-11-28 Online:2012-06-03 Published:2013-11-06
  • Contact: Wu Dong-cheng, Doctoral supervisor, Department of Biochemistry, Wuhan University, Wuhan Hongqiao Brain Hospital, Wuhan 430071, Hubei Province, China bcdcwu@hotmail.com
  • About author:Wang Ge, Wuhan University, Wuhan 430071, Hubei Province, China gege3192@126.com

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Abstract:

BACKGROUND: At present, there lacks effective repair approach for atrophy and necrosis of spinal nerve of spinal cord injury patients in the clinic. Bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injury has wide application prospects.
OBJECTIVE: To summarize the progress of bone marrow mesenchymal stem cells transplantation for the treatment of spinal cord injury.
METHODS: The first author searched PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://g.wanfangdata.com.cn/) for literatures concerning bone marrow mesenchymal stem cells, spinal cord injury and cell transplantation from 2001 to 2011. Key words were “bone marrow mesenchymal cells, spinal cord injury, cell transplantation” in English. Duplicate articles were excluded. Finally, 32 articles were selected to summarize.
RESULTS AND CONCLUSION: The research of bone marrow mesenchymal stem cells transplantation for treatment of spinal cord injury has made achievements in the spinal cord injury model establishment, transplantation time and approach, concentration and combined transplantation. Although clinical trials have been carried out at home and abroad, the mechanism was not very clear yet. The safety and efficacy of clinical treatment need further investigation.

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