Cytokines regulate osteochondral differentiation of stem cells

doi:10.3969/j.issn.2095-4344.2012.49.033

Abstract

Abstract:

BACKGROUND: Cartilage repair, especially with the subchondral bone damage, has been a hot research. In recent years, with the further research of cytokines, increasing attention has been paid to find a proper cytokine and induce osteochondral differentiation of stem cells.
OBJECTIVE: To review the regulatory effects of cytokines on osteochondral differentiation of stem cells.
METHODS: A computer-based online search of Pubmed database (http://www.Ncbi.nlm.nih.gov/PubMed) and Wanfang database (http://ww.wanfangdata.com.cn/) was performed for related articles published from January 2000 to December 2011 using the key words “chondrification, cytokine, stem cells, tissue engineering” in English and Chinese. Totally 32 papers were included in the final analysis.
RESULTS AND CONCLUSION: Cytokines, in particular, Wnt and transforming growth factor β/bone morphogenetic protein signaling pathways, play an important role in the osteochondral differentiation of stem cells. An in-depth study of various regulatory factors during the differentiation of stem cells would provide better conditions for in vitro culture and directed differentiation of stem cells in vitro.

CLC Number:

R318

Xu Sheng-gui, Lin Jian-hua. Cytokines regulate osteochondral differentiation of stem cells[J]. Chinese Journal of Tissue Engineering Research, 2012, 16(49): 9306-9310.

Figures/Tables 1

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