Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (26): 4892-4897.doi: 10.3969/j.issn.1673-8225.2012.26.028

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Pathogenesis of aseptic prosthesis loosening after artificial prosthesis implantation

Ma Yu-chao1, Tian Jing2   

  1. 1Second Clinical Medical College of Southern Medical University, Guangzhou 510282, Guangdong Province, China;
    2Department of Orthopedics Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China
  • Received:2011-11-13 Revised:2011-12-14 Online:2012-06-24 Published:2013-11-02
  • Contact: Tian Jing, Professor, Associate chief physician, Master’s supervisor, Department of Orthopedics Center, Affiliated Zhujiang Hospital of Southern Medical University, Guangzhou 510282, Guangdong Province, China tian_jing6723@yahoo.com.cn
  • About author:Ma Yu-chao, Second Clinical Medical College of Southern Medical University, Guangzhou 510282, Guangdong Province, China mycbyts@126.com

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Abstract:

BACKGROUND: There are many clinical researches on aseptic loosening of artificial prosthesis, but the exact pathogenesis is still unclear.
OBJECTIVE: To review the pathogenesis of prosthesis aseptic loosening after artificial prosthesis implantation.
METHODS: A computer-based online search of PubMed and CNKI was performed to search related articles published between 2006 and 2011 with the key words of “artificial prosthesis, aseptic loosening” both in English and Chinese. A total of 77 articles were obtained, and finally 38 articles were included.
RESULTS AND CONCLUSION: Aseptic loosening after long-term total hip replacement is one of the main failure reasons. In the recent years, analysis of revision total hip replacement for failed hip arthroplasty showed that aseptic loosening is the chief reason. The mechanism of aseptic loosening mainly includes mechanical mechanisms, biological and other mechanisms. With further research and the improvement of implantation method and prosthetic materials, aseptic loosening will eventually be minimized, so that the service life of prosthesis will be longer.

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