Abstract:

BACKGROUND: In recent years, with gradually further understanding the mechanism of the formation of inflammatory membrane and osteoclasts and activation, application of drugs to reverse the pathology of aseptic loosening of artificial joints has achieved fruitful progress.
OBJECTIVE: To review the pathogenesis and therapy progress of aseptic loosening of artificial joint.
METHODS: PubMed database was retrieved for articles with the key words of “Artificial joints, Aseptic loosening, Osteoclast, Tumor necrosis factor-a, Interleukin-1, Drug treatment, Gene Therapy, Bone loss” in English, and CNKI database was also retrieved with the key words of “artificial joints, prosthesis aseptic loosening, osteoclasts, tumor necrosis factor-a, interleukin-1, drug therapy, gene therapy, bone loss” in Chinese. Articles related to the pathogenesis of aseptic loosening of the prosthesis and drugs for aseptic loosening of the prosthesis prevention were included, and duplicate documents were eliminated.
RESULTS AND CONCLUSION: Totally 29 articles were included for review. Drugs for aseptic loosening of artificial joint were mostly involved in clinical use. Emphasis and difficulty of the current study is how to decrease adverse reactions and increase effective local drug concentration around the prosthesis in long term use of these drugs. In recent years, transgenic approach used to prevent and treat aseptic loosening of prosthesis is the latest research progress, although significant results have been achieved, human security of gene therapy is unresolved, therefore, these studies still are in vitro and animal experiments.