Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (26): 4898-4902.doi: 10.3969/j.issn.1673-8225.2012.26.029

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Prethrombotic state gene predictions and diagnosis of venous thromboembolism after large traumatic surgery including orthopedic joint replacement and implant placement

Wang Qiang, Zhao Xue-ling   

  1. Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
  • Received:2011-10-29 Revised:2011-11-06 Online:2012-06-24 Published:2013-11-02
  • Contact: Zhao Xue-ling, Doctoral supervisor, Professor, Chief physician, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China zhaoxuelin@vipkm169net
  • About author:Wang Qiang★, Studying for master’s degree, Department of Orthopedics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China 1289229840@qq.com

Abstract:

BACKGROUND: At present, we pay more attention on the early genetic diagnosis of venous thromboembolism after traumatic or orthopedic surgery.
OBJECTIVE: To summarize the mature gene research used to diagnosis the venous thromboembolism after orthopedic surgery.
METHODS: CNKI database and PubMed database (2000-01/2011-01) were searched through Web with the key words of “venous thrombosis, deep venous thrombosis, pulmonary embolism, genes, diagnosis” or “thrombosis, DVT, PE, gene”.
RESULTS AND CONCLUSION: Recent clinical and basic research showed that venous thromboembolism was a typical polygenic hereditary disease. And we also found some mutant gene related to high blood coagulation was closely related with venous thrombosis. These mutant gene included prothrombinase V, antithrombin Ⅲ, protein C, protein S, plasminogen, fibrinogen, heparin cofactor Ⅱ, thrombomodulin and prothrombinase Ⅻ. Understanding of the hereditary pathogenic gene mechanism for venous thromboembolism was in favor of early diagnosis and treatment and reduced the harm.

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