Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (45): 8516-8520.doi: 10.3969/j.issn.1673-8225.2010.45.037

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Autologous bone marrow mesenchymal stem cells transplantation for early avascular necrosis of the femoral head in 44 cases

Zhu Bing1, Sun Tian-sheng1, Zhou Jun2, Yao Jian-hua1, Wu Jun1, Chang Hong-xing1, Ren Da-jiang1   

  1. 1 Institute of Traumatology and Orthropedics, 2 Department of Blood Transfusion, General Hospital of Beijing Military Area Command of Chinese PLA, Beijing  100700, China
  • Online:2010-11-05 Published:2010-11-05
  • Contact: Sun Tian-sheng, Master, Chief physician, Professor, Institute of Traumatology and Orthropedics, General Hospital of Beijing Military Area Command of Chinese PLA, Beijing 100700, China suntiansheng-@163.com
  • About author:Zhu Bing★, Master, Associate chief physician, Institute of Traumatology and Orthropedics, General Hospital of Beijing Military Area Command of Chinese PLA, Beijing 100700, China orclin@sina.com
  • Supported by:

    the Capital Medical Development Foundation Program of China, No. 2005-3043*

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Abstract:

BACKGROUND: Avascular necrosis of the femoral head (ANFH) is deficient in mesenchymal stem cells and their function for osteogenesis is lower than normal. The sclerotic bands affect bone repair. It is necessary that detailed result analysis of autologous bone marrow mesenchymal stem cells transplantation with core decompression that can improve blood transport and contribute to bone repair to early stage of ANFH.
OBJECTIVE: To analyze results of follow up for early ANFH after autologous bone marrow mesenchymal stem cells transplantation and core decompression.
METHODS: From May 2005 to September 2008, forty-four patients with early ANFH were enrolled. All 76 hips were in the stage of 1-2 of ARCO staging system. All enrolled patients received concentrated autologous bone marrow stem cell injection and combined core decompression. ARCO1 patients were subjected to stem cell suspension injection, and ARCO2 patients were subjected to core decompression following transplantation. Harris scoring was used to evaluate the outcomes.
RESULTS AND CONCLUSION: Till March 2009, follow up was performed (22.3±4.2) months. Pain relief and function improved in 66 hips (86.9%); another 10 hips collapsed to stage 3-4 and total hip arthroplasty was performed in 3 cases. Results indicate that it is an effective and simple procedure for early ANFH using autologous bone marrow mesenchymal stem cells transplantation and core decompression. According to cytopathology of ANFH, our method is more reasonable than other procedures. Better clinical results would be achievable when carrying out in larger scale.

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