Abstract:

BACKGROUND: Bone marrow mesenchymal stem cells (BMSCs) affected by different environmental and biological factors in vitro can transform into cartilage cells, which is the focus of cartilage tissue engineering study in recent years.
OBJECTIVE: To summarize the effects of cytokines, stress stimulation, three-dimensional structure on BMSCs differentiation into cartilage cells.
METHODS: The databases of China National Knowledge Infrastructure and Pubmed were searched for the articles about BMSCs differentiation into chondrocytes published from January 2001 to June 2010. The key words were “bone marrow mesenchymal stem cells, chondrocyte, differentiation”, which used by inputting in titles and abstracts. The articles addressing BMSCs differentiation into chondrocytes were included. Those in the same field published recently or in authorized journals were included. There were 109 articles after the initial survey. Totally, 26 articles were included in accordance with inclusion criteria.
RESULTS AND CONCLUSION: Cytokines, stress stimulation, three-dimensional structure effects on BMSCs differentiation into cartilage cells was significant. The conditions for optimizing these factors can be more easily induced to differentiate into chondrocyte phenotype. With the deep understanding of BMSCs differentiation into cartilage cells, the application of these factors will be more extensive.