Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 167-170.doi: 10.3969/j.issn.1673-8225.2011. 01.038

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Application of umbilical cord mesenchymal stem cell transplantation in the treatment of two cases of hereditary spastic paraplegia 

Yang Hua-qiang1,2, Wang Yun-fu3, Li Dong-sheng1, Du Ling1, Yuan Ya-hong1, Jiang Hua2   

  1. 1Cell Therapy Center, 2Department of Hematology, 3Department of Neurology, Taihe Hospital Affiliated to Hubei Medical University, Shiyan  442000, Hubei Province, China
  • Received:2010-09-10 Revised:2010-10-10 Online:2011-01-01 Published:2011-01-01
  • About author:Yang Hua-qiang★, Master, Associate chief physician, Cell Therapy Center, Taihe Hospital Affiliated to Hubei Medical University, Shiyan 442000, Hubei Province, China; Department of Hematology, Taihe Hospital Affiliated to Hubei Medical University, Shiyan 442000, Hubei Province, China yanghuaqiang2004@126.com
  • Supported by:

    the Youth Science and Technology Talent Foundation of Hubei Province, No. QJX2008-38

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Abstract:

BACKGROUND: Hereditary spastic paraplegia is a kind of nervous system genetic disease which has clinical and genetic heterogeneity. Now, the treatment effectiveness of this disease is poor.
OBJECTIVE: To observe the clinical effect and safety of umbilical cord mesenchymal stem cells (UC-MSCs) transplantation in the treatment of hereditary spastic paraplegia (HSP).
METHODS: Two patients with HSP received UC-MSCs transplantation which total cellular score of UC-MSCs was (2-6)×107 by intravenous infusion and lumbar puncture intrathecal injections. Both patients were followed up after transplantation. Clinical symptoms and various indexes were observed and literature review was performed.
RESULTS AND CONCLUSION: After transplantation, the clinical symptoms of both patients improved obviously: muscle tonus of both lower extremities reduced obviously, independent ambulation independent of crutches and another person’s aid, and walking was stable. Various biochemical indicators were normal and both patients had no severe complications or clear side effects after transplantation. Both patients’ conditions were continuously catabatic and no recurrence was found after one year follow up. These indicated that UC-MSCs transplantation is effective and can ameliorate clinical manifestations and delay progression of the disease in the treatment of HSP.

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