Meta-analysis of the clinical efficacy of high-intensity interval exercise and middle-intensity continuous training in patients with coronary heart disease

doi:10.12307/2026.625

Abstract

Abstract: OBJECTIVE: Although existing studies have suggested that high-intensity interval training may be more effective than moderate-intensity continuous training in improving cardiopulmonary function in patients with coronary heart disease, its clinical efficacy remains controversial. Therefore, this meta-analysis aims to systematically evaluate the clinical efficacy of high-intensity interval training versus moderate-intensity continuous training in patients with coronary heart disease.
METHODS: Randomized controlled trials of high-intensity interval training and moderate-intensity continuous training in cardiac rehabilitation of coronary heart disease were included by searching Chinese and English databases such as CNKI, WanFang Database, Wipro, PubMed, Cochrane Library, Embase, and Web of science. Meta-analysis of the final included literature was performed using Review Manager 5.3 and StataMP 17.
RESULTS: A total of 10 studies met the study criteria and included 773 patients. Compared with moderate-intensity continuous training, high-intensity interval training resulted in higher peak oxygen uptake and oxygen uptake at the first ventilatory threshold were higher [mean difference=1.30, 95% confidence interval (0.71, 1.89), P < 0.000 1; mean difference=1.54, 95% confidence interval (0.56, 2.53), P=0.002]. Both groups showed no significant difference in resting systolic blood pressure, resting diastolic blood pressure, resting heart rate and peak heart rate (P > 0.05).
CONCLUSION: Compared with moderate-intensity continuous training, high-intensity interval training is more advantageous in improving peak oxygen uptake and oxygen uptake at the first ventilation threshold in coronary artery disease, while has no significant effects on resting heart rate, peak heart rate, resting systolic blood pressure, and resting diastolic blood pressure.

Key words: coronary heart disease, high-intensity interval exercise, moderate-intensity aerobic exercise, cardiac rehabilitation, clinical efficacy, randomized controlled trial, meta-analysis

CLC Number:

Hu Yujie, Xie Ping, , Lu Weijie, Yang Kang, Deng Yaoting, Liu Mengyang. Meta-analysis of the clinical efficacy of high-intensity interval exercise and middle-intensity continuous training in patients with coronary heart disease[J]. Chinese Journal of Tissue Engineering Research, 2026, 30(10): 2584-2593.

Figures/Tables 9

到受试者盲法与结果评估者双盲，但其中4篇文献明确提及对结果评估者采用盲法；所有研究均未发现数据缺如、选择性报告研究成果及其他偏倚来源。文献质量评价结果见图4，5。 2.3 Meta分析结果 2.3.1 峰值摄氧量 8篇文献报道了高强度间歇训练干预对冠心病患者峰值摄氧量的影响[6-10，12，14-15]。异质性检验显示P=0.006、I2=65%，见图6，提示文献之间存在明显异质性。对文献进行敏感性分析，结果提示MARCIN等[10] 文章对总体效应量影响较大，见图7，剔除该篇文章后再次进行异质性检验，结果显示P=0.29、I2=19%，提示文献之间异质性消除。采用固定效应模型计算效应量，结果显示高强度间歇训练组峰值摄氧量高于中等强度持续训练组[MD=1.30，95%CI(0.71，1.89)，P < 0.000 1]，见图8。 2.3.2 第一通气阈时摄氧量 6篇文献报道了高强度间歇训练干预对冠心病患者第一通气阈时摄氧量的影响[6-7，9，13-15]。异质性检验显示P=0.09、I2=47%，见图9，提示文献之间存在轻微异质性。经敏感性分析未发现存在明显影响总体效应量的文章，并且文献之间异质性在可接受范围内，见图10，因此选用随机效应模型计算效应量，结果提示高强度间歇训练组第一通气阈时摄氧量高于中等强度持续训练组[MD=1.54，95%CI(0.56，2.53)，P=0.002]，见图11。 2.3.3 静息心率 5篇文献报道了高强度间歇训练干预对冠心病患者静息心率的影响[6-8，12，15]。异质性检验显示P=0.23、I2=28%，提示文献之间不存在异质性，故选用固定效应模型计算效应量，结果显示两组间静息心率比较差异无显著性意义[MD=0.92，95%CI(-0.77，2.62)，P=0.29]，见图12。 2.3.4 峰值心率 8篇文献报告了高强度间歇训练干预对冠心病患者峰值心率的影响[6，8-13，15]。异质性检验显示P=0.03、I2=56%，见图13，提示文献之间存在异质性。敏感性分析结果显示，MARCIN等[10]的文章对总体效应量影响较大，剔除该篇文章后异质"

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