Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (10): 1505-1511.doi: 10.12307/2024.320
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Wu Yangpeng1, Yang Xiaohui2, Lao Kecheng2, Dai Shiyou2, Fan Xiao2
Received:
2023-03-24
Accepted:
2023-05-19
Online:
2024-04-08
Published:
2023-08-17
Contact:
Fan Xiao, Attending physician, Qingdao Hospital (Qingdao Municipal Hospital), University of Health and Rehabilitation Sciences, Qingdao 266011, Shandong Province, China
About author:
Wu Yangpeng, Master, Physician, Department of Traditional Chinese Medicine Rehabilitation, The 909 Hospital of Joint Logistic Support Force (Dongnan Hospital of Xiamen University), Zhangzhou 363000, Fujian Province, China
Supported by:
CLC Number:
Wu Yangpeng, Yang Xiaohui, Lao Kecheng, Dai Shiyou, Fan Xiao. Characterization and repair effect of supramolecular conducting hydrogel carrying ligustrazine on spinal cord injury in rats[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(10): 1505-1511.
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2.2 携川芎嗪超分子导电水凝胶的表征分析结果 傅里叶红外变换光谱仪检测结果显示,在纯聚吡咯的红外光谱图中,1 033 cm-1处的吸收峰对应了C-H键的平面内弯曲振动,1 390 cm-1处的吸收峰对应着C-N键的伸缩振动峰,3 200-3 630 cm-1处的宽峰是羟基基团的吸收峰;对比3 张傅里叶红外光谱图可以看到,聚吡咯-琼脂光谱图包含了聚吡咯和琼脂的特征峰(图3A),这为聚吡咯在携川芎嗪超分子导电水凝胶发挥导电性方面提供了有力的证据。 利用DDS-308A型电导率仪在室温下检测携川芎嗪超分子导电水凝胶的电导率,均值为7.66 S/m(图3B),这个区间正处在适合神经元轴突再生的导电率范围(1-10 S/m)[25]。在膨胀率方面,携川芎嗪超分子导电水凝胶在去离子水中的溶胀率为3 764.42%,与对照组相比保持了较高的溶胀能力,说明在添加了水溶性导电聚合物聚吡咯后琼脂水凝胶优秀的溶胀性能并没有遭到破坏,二者性状无明显差异(图3C)。 采用流变仪测量携川芎嗪超分子导电水凝胶的储存模量(G’)和损耗模量(G″),在角频率范围(0.1-500 rad/s)内,水凝胶的储存模量均高于损耗模量(图3D),说明携川芎嗪超分子导电水凝胶具备一定的力学稳定性能,不会因为机械强度过低而在周围组织应力作用下变形或流失,同时具备良好的可注射性。 "
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