Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (9): 1378-1382.doi: 10.12307/2023.924

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Changes in muscle strength and pain in patients receiving Jianpi Yiqi Huoxue Formula after total knee arthroplasty

Shan Jiaxin1, Zhang Yilong1, Wu Hongtao1, Zhang Jiayuan1, Li Anan2, Liu Wengang2, Xu Xuemeng2, Zhao Chuanxi2   

  1. 1Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China; 2Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Academy of Traditional Chinese Medicine Engineering and Technology), Guangzhou 510095, Guangdong Province, China
  • Received:2022-12-16 Accepted:2023-02-11 Online:2024-03-28 Published:2023-07-25
  • Contact: Zhao Chuanxi, Master, Master’s supervisor, Chief TCM physician, Guangdong Second Traditional Chinese Medicine Hospital (Guangdong Academy of Traditional Chinese Medicine Engineering and Technology), Guangzhou 510095, Guangdong Province, China
  • About author:Shan Jiaxin, Master candidate, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
  • Supported by:
    Scientific Research Project of Traditoral Chinese Medcine Bureau of Guangdong Province, No. 20223004 (to ZCX); Guangdong Provincial Science and Technology Plan Project, No. 2021B1111610007 (to XXM); Guangzhou Science and Technology Plan Project, No. 202206010048 (to XXM); Guangdong Medical Science and Technology Research Fund Project, No. A2021463 (to LWG)

Abstract: BACKGROUND: Some patients still have unsatisfactory improvement of operative limb fatigue and pain after total knee arthroplasty. Clinical findings show that Jianpi Yiqi Huoxue Formula can promote recovery after total knee arthroplasty, but the specific efficacy remains to be studied. 
OBJECTIVE: To observe the effect of Jianpi Yiqi Huoxue Formula on the muscle strength and pain of the operated limb after the primary unilateral total knee arthroplasty. 
METHODS: A total of 74 patients undergoing primary unilateral total knee arthroplasty were randomly divided into a trial group and a control group with 37 patients in each group. All patients received the same prostheses and surgical methods during the operation. Patients in the control group were treated with routine analgesics, anticoagulant drugs and functional exercise after the operation. The trial group received Jianpi Yiqi Huoxue Formula after the treatment in the control group. Both groups were treated continuously and followed up for 1 month. The changes in isokinetic muscle strength (peak torque and total work amount of extensor and flexor), visual analog scale score and the hospital for special surgery score of the two groups were analyzed. 
RESULTS AND CONCLUSION: (1) The trial group had better improvement in peak torque and total work amount of extensor and flexor and the hospital for special surgery score than the control group 14 days and 1 month after surgery (P < 0.05). (2) In contrast to the control group, the visual analog scale score of the trial group improved better at 7 and 14 days and 1 month after surgery (P < 0.05). (3) It is indicated that Jianpi Yiqi Huoxue Formula can effectively improve the muscle strength of the operated limb, enhance the degree of postoperative joint pain, and promote functional rehabilitation after total knee arthroplasty. 

Key words: total knee arthroplasty, Jianpi Yiqi Huoxue Formula, muscle strength, pain, follow-up 

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