Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (23): 3760-3766.doi: 10.12307/2021.051
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Yang Wei1, Chen Zehua2, Yi Zhiyong3, Huang Xudong3, Han Qingmin3, Zhang Ronghua4
Received:
2020-10-17
Revised:
2020-10-20
Accepted:
2020-11-11
Online:
2021-08-18
Published:
2021-02-24
Contact:
Han Qingmin, MD, Chief physician, Professor, Doctoral supervisor, Department of Sports Medicine, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Co-corresponding author: Zhang Ronghua, MD, Chief physician, Professor, Doctoral supervisor, Jinan University, Guangzhou 510632, Guangdong Province, China
About author:
Yang Wei, MD candidate, Attending physician, The Third Clinical School of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China
Supported by:
CLC Number:
Yang Wei, Chen Zehua, Yi Zhiyong, Huang Xudong, Han Qingmin, Zhang Ronghua. Effectiveness of intra-articular injection of hyaluronic acid versus placebo in the treatment of early and mid-stage knee osteoarthritis: a Meta-analysis based on randomized, double-blind, controlled, clinical trials[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(23): 3760-3766.
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2.4.2 两组患者疼痛目测类比评分基线变化的差异 有5篇文献对比了两组治疗1,3,6个月后疼痛目测类比评分基线的变化[17,19, 22-23,27]。采用固定效应模型发现尽管所有时间点的差异均有显著性意义,但两组治疗1,3,6个月后各研究间统计学异质性均较高(P=0.07,I2=58%;P=0.03,I2=67%;P=0.12,I2=45%),改用随机效应模型,经敏感性分析分别剔除3个研究后异质性明显降低(P=0.53,I2=0%;P=0.27,I2=24%;P=0.26,I2=25%)[19,22-23],Meta分析结果(MD=2.71,95%CI:1.35-4.07,P < 0.000 1;MD=0.42,95%CI:-3.17-4.02,P=0.82;MD=3.14,95%CI:0.81-5.47,P=0.008),说明透明质酸治疗1,6个月疼痛的减轻明显优于安慰剂组,且差异有显著性意义,但治疗后3个月两组疼痛变化无显著差异。见图6。 "
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