Association between COL9A2 gene polymorphisms and intervertebral disc degeneration in Asian: a meta-analysis

doi:10.3969/j.issn.2095-4344.1158

Abstract

Abstract:

BACKGROUND: Sequencing of the human genome has found that gene mutation will lead to structural changes of intervertebral disc and increase the risk for degeneration.

OBJECTIVE: To investigate the association of rs12077871, rs12722877, and rs7533552 polymorphisms in the COL9A2 gene with intervertebral disc degeneration by meta-analysis.

METHODS: Databases of PubMed, Web of Science, CNKI and WanFang were searched for the articles addressing the association of rs12077871, rs12722877, and rs7533552 polymorphisms in the COL9A2 gene with intervertebral disc degeneration published before July 2018. The quality of the included studies was evaluated according to the principle of STREGA, and 6 articles involving 2 874 participants were eligible for inclusion and exclusion criteria. Distribution characteristics of different alleles and genotypes in the intervertebral disc degeneration (case group) and non-intervertebral disc degeneration (control group) underwent meta-analysis on Stata 12.0 software.

RESULTS AND CONCLUSION:(1) The results of meta-analysis showed that there was no significant differences association between the genotypes and allele frequency of rs12077871, rs12722877, and rs7533552 polymorphisms in COL9A2 gene and intervertebral disc degeneration. (2) Therefore, the rs12077871, rs12722877, and rs7533552 polymorphisms in COL9A2 gene are not associated with intervertebral disc degeneration in Asian. But, more high-quality multi-center and large-sampled case control studies are required to verify the conclusion.

Key words: intervertebral disk degeneration, COL9A2, gene polymorphisms, alleles, gene mutation, meta-analysis

CLC Number:

R446

Li Pengfei, Wang Tao, Ma Xinlong . Association between COL9A2 gene polymorphisms and intervertebral disc degeneration in Asian: a meta-analysis [J]. Chinese Journal of Tissue Engineering Research, 2019, 23(20): 3275-3280.

Figures/Tables 5

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