Degradability of poly(trimethylene carbonate) in vitro

doi:10.3969/j.issn.2095-4344.0944

Abstract

Abstract:

BACKGROUND: At present, the fallopian tube embolization devices have many malpractices because of the metal texture. Poly(trimethylene carbonate), a biodegradable material, is introduced to find a breakthrough in the field of tubal embolism materials.

OBJECTIVE: To observe the degradation behavior of poly(trimethylene carbonate) and to demonstrate the possibility of its use as a tubal embolization material.

METHODS: Poly(trimethylene carbonate) with different relative molecular weight was soaked in phosphate buffer and lipase solution at 37 ^oC with gently shaking. The degradation behavior of poly(trimethylene carbonate) was evaluated by observing the morphology, mass loss, relative molecular weight of the samples and the pH value of the degradation solution regularly.

RESULTS AND CONCLUSION: Poly(trimethylene carbonate) exhibited surface erosion degradation in vitro and the degradation products did not contain acid compounds. Lipase could accelerate the degradation process, but the shape and size of the samples were the main factors that affected the decline rate of molecular weight. The molecular weight of the samples affected the degradation rate and dimensional stability: the larger the relative molecular weight, the higher shape retention rate, but the faster mass loss; the smaller the relative molecular weight, the slower mass loss, but the more serious deformation. Therefore, poly(trimethylene carbonate) is expected to be used for fallopian tube embolization materials by selecting suitable molecular weight or adjusting its properties by copolymerization.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Biocompatible Materials, Biodegradation, Environmental, Fallopian Tubes

CLC Number:

R318

Zhang Wei, Li Hong-yuan, Yang Li-qun, Li Miao, Jin Ying, Yi Dong-xu. Degradability of poly(trimethylene carbonate) in vitro[J]. Chinese Journal of Tissue Engineering Research, 2018, 22(26): 4202-4207.

Figures/Tables 7

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