Development and application of a multifunctional impactor based on animal experiments

doi:10.3969/j.issn.2095-4344.2017.20.014

Abstract

Abstract:

BACKGROUND: A few devices have been reported to be used for studies on trauma, but these devices are unavailable for establishing the animal models of trauma because of their limited application range.

OBJECTIVE: To develop a multifunctional impact system and evaluate its application effect, thus paying ways for establishing the animal models of trauma and basic experiments.

METHODS: The multifunctional impact system was designed based on the theory of energy storage device, simple multifunctional impact device and impact parameter measuring equipment, and its effectiveness and stability were detected. The rat chest and different visceral organs were subjected to the closed impact experiment using a 5 cm² impact at the predetermined parameter of 200, 300, 400, 500 kPa, respectively. Afterwards, the rats were sacrificed for morphological observation.

RESULTS AND CONCLUSION: The multifunctional impactor was successfully developed, of which the maximum impact stress could be adjusted from 0 to 200 kg and compressive and extrusion stress also could be continuously adjusted from 0 to 100 kg. The experimental results showed that the impactor made certain damage to the rat lung, liver and spleen suggesting its favorable effectiveness (P < 0.05) and repeatability (P > 0.05). These findings suggest that the impactor is easy to operate in various ways and holds good effectiveness and stability, and its impact parameters can be detected in real time. Therefore, the impactor is suitable for both establishing the animal model of trauma and basic experiments.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Wounds and Injuries, Mechanics, Stress, Mechanical, Tissue Engineering

CLC Number:

R318

Wang Hai-lin, Xiao He-da, Zhang Sheng, Jiang Zong-xing, Liu Wei-hui, Tang Li-jun, Dai Rui-wu. Development and application of a multifunctional impactor based on animal experiments[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(20): 3196-3201.

Figures/Tables 2

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