Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (15): 2453-2460.doi: 10.3969/j.issn.2095-4344.2017.15.027

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Minimally invasive versus open transforaminal lumbar interbody fusion for spondylolisthesis: a meta-analysis  

Yan Bing-shan1, 2, Xu Bao-shan2, Liu Yue2, Yang Qiang2   

  1. 1Graduate School of Tianjin Medical University, Tianjin 300070, China; 2Tianjin Hospital, Tianjin 300211, China
  • Online:2017-05-28 Published:2017-06-07
  • Contact: Xu Bao-shan, M.D., Chief physician, Tianjin Hospital, Tianjin 300211, China
  • About author:Yan Bing-shan, Studying for master’s degree, Graduate School of Tianjin Medical University, Tianjin 300070, China; Tianjin Hospital, Tianjin 300211, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81272046 and 31670983; the Research and Development Program of Health and Family Planning Commission of Tianjin City, No. 14KG121; the Natural Science Foundation of Tianjin City, No. 15JCYBJC25300

Abstract:

BACKGROUND:Minimally invasive transforaminal interbody fusion (Mis-TLIF) for spondylolisthesis has been introduced to reduce muscle trauma, minimize blood loss, and achieve earlier rehabilitation. However, there is a lack of evidence-based medicine concerning the therapeutic efficacy of Mis-TLIF versus open TLIF for spondylolisthesis.
OBJECTIVE: To systematically evaluate the clinical efficacy and safety of Mis-TLIF versus open TLIF for spondylolisthesis.

METHODS: WanFang, CNKI, PubMed, and Cochrane Library databases were searched using the keywords of “spondylolisthesis, minimally invasive transforaminal interbody fusion, open transforaminal interbody fusion” in English and Chinese, respectively. The quality evaluation and data extraction of the included literatures were conducted by two authors independently. A meta-analysis was performed on RevMan 5.3 software.
RESULTS AND CONCLUSION: Ten literatures were included, including 7 retrospective and 3 randomized controlled trials; 963 cases were enrolled (489 cases of Mis-TLIF, 474 cases of open TLIF). (1) Meta-analysis results showed that there were no significant differences in the operation time, postoperative complication rate, and fusion rate at the last follow-up between two groups, suggesting that the two methods expose analogical effects on the pain relief and functional recovery. (2) There were significant differences in the intraoperative blood loss and radiological times between two methods. (3) To conclude, Mis-TLIF holds similar operation time, incidence of complications and functional recovery with open TLIF, accompanied by minimized trauma, and reduced intraoperative and postoperative blood loss, which is considered as a safe and effective surgical method.

中国组织工程研究杂志出版内容重点:人工关节;骨植入物;脊柱骨折;内固定;数字化骨科;组织工程

Key words: Spondylolysis, Surgical Procedures, Minimally Invasive, Spinal Fusion, Meta-Analysis, Tissue Engineering

CLC Number: