Magnetic resonance T2 mapping and T1ρ imaging of adult rhesus monkeys with lumbar intervertebral disc degeneration in free-range population

doi:10.3969/j.issn.2095-4344.2017.03.017

Abstract

Abstract:

BACKGROUND: Primates are considered to be the most appropriate animal model of lumbar intervertebraldisc degeneration, but the disc degenerated characteristics of monkeys were rarely reported.

OBJECTIVE: To verify the degenerated regularity and characteristics of lumbar intervertebral disks in rhesus monkeys with magnetic resonance T2 mapping and T1ρ imaging technology.

METHODS: The sagittal lumbar intervertebral disc magnetic resonance T2 weighted imaging,T2 weighted mapping imaging and T1ρ weighted imaging of 63 adult rhesus monkeys were acquired on 1.5T magnetic resonance equipment. The T2-map value and T1ρ value of lumbar intervertebral disc regions of interest were calculated on the post-processing workstation.

RESULTS AND CONCLUSION: (1) This study obtained 425 better magnetic resonance images of lumbar intervertebral disks in adult rhesus monkeys. T2-map value and T1ρ value of nucleus pulposus were most consistent by different persons, and the Kappa coefficient was more than 0.93. (2) The T2-map value and T1ρ value of nucleus pulposus were both negatively correlated significantly with Pfirrmann grades (r=-0.842, P < 0.01; r=-0.896, P < 0.01). The T1ρ value and T2-map value of nucleus pulposus were significantly statistically different between Pfirrmann grades I-IV (P < 0.001, P < 0.001). The T1ρ value of nucleus pulposus was negatively correlated significantly with Pfirrmann grade II-III (r=-0.517, P < 0.01) and Pfirrmann grade IV-V (r=-0.499, P < 0.01). The T2-map value of nucleus pulposus was also negatively correlated significantly with Pfirrmann grade II-III (r=-0.617, P < 0.01) and Pfirrmann grade IV-V (r=-0.652, P < 0.01). (3) The T2-map value of L₁_-₂ and L₂_-₃ segments nucleus pulposus were significantly lower than that in L_6-7 and L₇-S₁ segments (P < 0.05). (4) There were significant differences in age among the T1ρ value and T2-map value of nucleus pulposus (r=-0.702, P < 0.001, r=-0.730, P < 0.001). (5) It is concluded that magnetic resonance T2 mapping and T1ρimaging technology can objectively and sensitively assess the degenerated process of nucleus pulposus in rhesus monkeys. The degeneration in upper lumbar segments (L₁_-₂ and L₂_-₃) was earlier and more severe than that in lower lumbar segments (L₆_-₇ and L₇-S₁) in rhesus monkeys. Age is one of the most important factors in lumbar intervertebral disc degeneration of adult rhesus monkeys.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Intervertebral Disk, Magnetic Resonance Imaging, Macaca mulatta, Tissue Engineering

CLC Number:

R318

Chen Jiang-bo, Pan Xi-min, Chen Ying-ming, Wu Zhi-qiang, Meng Zhong-meng, Chen Li-qiang, Zhuang Wen-quan. Magnetic resonance T2 mapping and T1ρ imaging of adult rhesus monkeys with lumbar intervertebral disc degeneration in free-range population [J]. Chinese Journal of Tissue Engineering Research, 2017, 21(3): 418-422.

Figures/Tables 3

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