Effects of recombinant human epidermal growth factor gel combined with nano-silver dressing for burn scar

doi:10.3969/j.issn.2095-4344.2015.25.014

Abstract

Abstract:

BACKGROUND: Recombinant human epidermal growth factor has been shown to promote granulation tissue formation and to accelerate the healing of burn wounds, but the antibacterial effect of recombinant human epidermal growth factor is limited.
OBJECTIVE: To investigate the effect of nano-silver dressing combined with recombinant human epidermal growth factor gel in treatment of burns and the influence on the scar.
METHODS: A total of 76 cases of shallow II and depth II degree were randomly enrolled and assigned to two groups. In the study group, recombinant human epidermal growth factor was coated on the surface of the wound, and then covered by nano-silver dressing. In the control group, recombinant human epidermal growth factor was coated on the surface of the wound, and covered by ordinary sterile gauze. The healing time, the positive rate of bacteria, scarring and adverse reactions were compared between the two groups.
RESULTS AND CONCLUSION: The wound healing time and the rate of hypertrophic scars after healing were
lower in the study group than in the control group (P < 0.01). The rate of flat scar was greater in the study group than in the control group after healing (P < 0.01). The bacterial positive rate was significantly lower in the study group than in the control group at 7, 14 and 21 days after treatment (P < 0.05). No significant difference in incidence of allergies and local burning sensation was detected between the two groups (P > 0.05). These data confirmed that recombinant human epidermal growth factor gel combined with nano-silver dressing in the treatment of burn has good efficacy and accelerates the wound healing, reduces scar formation, and improves aesthetics.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Epidermal Growth Factor, Gels, Biological Dressings, Burns

CLC Number:

R318

Jiao Jian-qiang, Li Ye, Huang Zhe, Hu Wei-guang . Effects of recombinant human epidermal growth factor gel combined with nano-silver dressing for burn scar[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(25): 4007-4011.

Figures/Tables 1

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