Mesenchymal stem cells for liver cirrhosis: problems and prospects

doi:10.3969/j.issn.2095-4344.2015.19.025

Abstract

Abstract:

ACKGROUND: Studies have shown that under certain conditions, mesenchymal stem cells can be induced to differentiate into hepatocytes and promote local angiogenesis to generate new capillary network and build rich collateral circulation for the purpose of improvement and treatment of liver cirrhosis.
OBJECTIVE: To review the latest advances in mesenchymal stem cell transplantation for the treatment of liver cirrhosis.
METHODS: PubMed, CNKI, Wanfang and VIP databases were searched using keywords of “marrow stem cells, hepatic cirrhosis” in the title and abstracts for articles addressing mesenchymal stem cell transplantation for liver cirrhosis published from January 2000 to December 2014. Finally, 53 articles were reviewed.
RESULTS AND CONCLUSION: Mesenchymal stem cells have self-replication and multi-directional differentiation potential, and also possess paracrine and immune functions, which are ideal seed cells used for cell replacement therapy. At present, the techniques for isolation, culture, identification and in vitro amplification of mesenchymal stem cells have been quite mature, and animal studies have confirmed that umbilical cord mesenchymal stem cells is safe and effective to treat decompensated cirrhosis, which can fundamentally treat target organ damage and improve liver function, but there are still many clinical issues to be resolved.

Key words: Liver Cirrhosis, Liver Regeneration, Mesenchymal Stem Cells, Hepatic Stellate Cells

CLC Number:

R318

Li Cui-fang, Yao Yuan. Mesenchymal stem cells for liver cirrhosis: problems and prospects[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(19): 3102-3106.

Figures/Tables 1

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