Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (6): 1046-1049.doi: 10.3969/j.issn.1673-8225.2012.06.022

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Membranous nephropathy after allogeneic hematopoietic stem cells transplantation in one case

Dong Xiu-juan1, Zhou Kai1, Jiao Xue-li1, Chen Lei1, Liu Meng-meng2, Han Li-jie1, Su Li3, Wu Fan1, Zhao Xiao-wu1   

  1. 1Department of Hemotology; 2Department of Pathology; 3Department of Laboratory Medicine, the Third People’s Hospital of Zhengzhou, Zhengzhou  450000, Henan Province, China 
  • Received:2011-07-19 Revised:2011-09-23 Online:2012-02-05 Published:2012-02-05
  • Contact: Zhao Xiao-wu, Chief physician, Department of Hemotology, the Third People’s Hospital of Zhengzhou, Zhengzhou 450000, Henan Province, China zhaoxiaowu@medmail.com.cn
  • About author:Dong Xiu-juan, Associate chief physician, Department of Hemotology, the Third People’s Hospital of Zhengzhou, Zhengzhou 450000, Henan Province, China wudongxiujuan@163.com

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Abstract:

BACKGROUND: Graft-versus-host disease (GVHD) in patients is closely related with membranous nephropathy.
OBJECTIVE: To investigate the clinical features of renal damage associated with allogeneic hematopoietic stem cells transplantation (Allo-HSCT) in order to do the early diagnosis of GVHD.
METHODS: A retrospective analysis of clinical presentation and the follow-up therapy and vesting of 1 case of membranous nephropathy after acute leukemia Allo-HSCT.
RESULTS AND CONCLUSION: The clinical manifestations in patient were severe proteinuria, hyperlipidemia, hypoalbuminemia and other features of nephrotic syndrome, and dry eyes, dry mouth and other performance of chronic graft-versus-host disease (cGVHD) was increased. Pathological diagnosis of membranous nephropathy was made. After the treatment of immunosuppressants such as prednisone, tacrolimus and triptolide for 4 months, the proteinuria was negative, clinical symptoms were improved. Up for 3 years without recurrent disease and the life quality was better. Chronic kidney damage is a special performance of cGVHD after Allo-HSCT and the vesting is good with the treatment of immunosuppressive therapy, pathological examination of renal was important for diagnosis.

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