Abstract:

BACKGROUND: The injured nerve has no self-repair ability, therefore, nerve tissue engineering scaffolds have achieved increasing attention involving nerve repair and promotion of neural regeneration.
OBJECTIVE: To analyze the application and efficacy of the commonly used nerve tissue engineering scaffolds.
METHODS: The polymer materials which were consisted of collagen, chitosan, gelatin, hyaluronic acid and synthetic materials for the repair of nerve injury were explored in animal models. The structure and physiological functions of the regenerated nerve were observed with immunohistochemical staining and biochemical assay. Thus the application prospect of different nerve tissue engineering scaffolds was observed.
RESULTS AND CONCLUSION: Nerve tissue engineering scaffold materials, such as collagen, chitosan, gelatin, hyaluronic acid and synthetic materials, are all effective in the repair process of nerve injury and regeneration through different ways, they can combine with cells for a biological polymerization, also combines with nerve fragment transplantation to form bridge connecting conduit in the injured nerve, obtaining therapeutic effect in animal model experiments.