Abstract:

BACKGROUND: At present, there are several reports about studies on bio-derived and inorganic-derived bone tissue substitutes. But the difference between the two bone materials in bone augmentation guided by calvarial defects and osteogenic effects is debatable.
OBJECTIVE: To compare the ability of guiding new bone regeneration between the two bone materials during the repair of calvarial defects in rabbits.
METHODS: A rabbit model of calvarial defects with three 8 mm diameter holes was established. The front and rear bone defects areas were filled separately with inorganic-derived and bio-derived bone materials. The middle bone defects areas were only covered with collagen membranes as a control.
RESULTS AND CONCLUSION: At weeks 12, 16 and 24 after treatment, the Masson’s trichrome staining image showed that the new bone quantity of the two bone materials was obviously more than that of the blank control group at each time point; and the new bone quantity in the bio-derived bone materials group was obviously more than that of the inorganic-derived bone materials group at each time point (P ≤ 0.05). These results suggest that inorganic-derived and bio-derived bone materials can both guide new bone regeneration for repairing bone defects, but the effectiveness of bio-derived bone materials is superior to that of the inorganic-derived bone materials.