Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (46): 8629-8635.doi: 10.3969/j.issn.2095-4344.2012.46.016

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mRNA expression of insulin-like growth factor-1 and its receptor in pathological scars

Cai Hao1, 2, Tang Bing1, Zhu Jia-yuag1, Zhu Bin1, Bi Liang-kuan1   

  1. 1Department of Burn Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 5180080, Guangdong Province, China
    2Third Department of General Surgery, People’s Hospital of Huidong County, Huidong 526300, Guangdong Province, China
  • Received:2012-08-11 Revised:2012-10-23 Online:2012-11-11 Published:2013-03-16
  • Contact: Zhu Jia-yuan, Doctor, Chief physician, Doctoral supervisor, Professor, Department of Burn Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 5180080, Guangdong Province, China zhujiayuan@163.net
  • About author:Cai Hao★, Master, Associate chief physician, Department of Burn Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 5180080, Guangdong Province, China; Third Department of General Surgery, People’s Hospital of Huidong County, Huidong 526300, Guangdong Province, China dayu1995@sina.com Zhu Jia-yuan, Doctor, Chief physician, Doctoral supervisor, Professor, Department of Burn Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 5180080, Guangdong Province, China zhujiayuan@163.net Cai Hao and Zhu Jia-yuan contributed equally to this study.

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Abstract:

BACKGROUND: In many tumors, insulin-like growth factor 1 and its receptor express abnormally. Insulin-like growth factor is the mitogen and anti-apoptotic factor of a variety of cells, controlling the proliferation, differentiation and apoptosis of various cells.
OBJECTIVE: To observe the expression of insulin-like growth factor-1 and insulin-like growth factor -1 receptor in pathological scar.
METHODS: Surgical specimens of hypertrophic scars, keloids and normal skin were collected from the patients admitted in the Department of Burn Surgery, First Affiliated Hospital of Sun Yat-sen University. Fluorescent quantitative real-time PCR technique was used to detect the mRNA expression of insulin-like growth factor-1 and insulin-like growth factor -1 receptor in different tissues.
RESULTS AND CONCLUSION: The mRNA expression of insulin-like growth factor-1 was higher in the hypertrophic scars and keloids than in the normal skin (P < 0.05). However, there was no difference in the mRNA expression of insulin-like growth factor-1 between the hypertrophic scars and keloids (P > 0.05). The expression of insulin-like growth factor-1 receptor in the hypertrophic scars was close to that in the normal skin (P > 0.05); while, the expression of insulin-like growth factor-1 receptor in the keloids was significantly higher than that in the surrounding tissues of keloids (P < 0.05). These findings indi

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