Abstract:

BACKGROUND: Skin wound healing is a complex pathological process, and the research on the difficult healing of skin caused by trauma and post-traumatic infections is the clinical wound healing problem. There are many basic studies on basic fibroblast growth factor promoting skin wound healing, but the clinical studies are rare.
OBJECTIVE: To multi-levelly analyze the effect of basic fibroblast growth factor in promoting skin wound healing and to explore the application efficacy in pediatric burn wound healing.
METHODS: A computer-based search was performed in CNKI database from January 2002 to December 2011 for the literatures on the effect of basic fibroblast growth factor in promoting skin wound healing. The key words were “basic fibroblast growth factor, wound healing” in Chinese. The data characteristics were analyzed by the analysis capabilities of the database and Excel chart function.
RESULTS AND CONCLUSION: There were 228 literatures on the effect of basic fibroblast growth factor in promoting skin wound healing obtained in the CNKI database from 2001 to 2011, and the number of literatures was in the stable development trend. A total of 26 literatures were obtained in the Journal of Clinical Rehabilitative Tissue Engineering Research, and most of the literatures were published by the 304 Hospital of Chinese PLA. The 76 literatures on the effect of basic fibroblast growth factor in promoting skin wound healing were supported by 16 projects. Most of the literatures were supported by the “National Key Basic Research Development Planning Project (973)” and “National Natural Science Foundation of China”. The literatures related to the application of basic fibroblast growth factor in pediatric burn wound healing are rare, but the experimental results show the effect is good, indicating that basic fibroblast growth factor plays an important role in promoting the pediatric Ⅱ degree burn wound healing without adverse reaction.