Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (25): 4654-4658.doi: 10.3969/j.issn.1673-8225.2012.25.019

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Non-isothermal crystallization kinetics of degradable copolymer based on epsilon-caprolactone and D, L-lactide

Yang Li-qun, Yang Dan, Li Jian-xin, Guan Yan-min, Li Miao   

  1. Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China
  • Received:2011-12-11 Revised:2012-01-12 Online:2012-06-17 Published:2013-11-04
  • Contact: Yang Dan, Research fellow, Liaoning Research Institute of Family Planning, Shenyang 110031, Liaoning Province, China yangdan0108@ 126.com
  • About author:Yang Li-Qun☆, Studying for doctorate, Research assistant, Liaoning Research Institute of Family Planning, Shenyang 10031, Liaoning Province, China yangliqun21@ 163.com

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Abstract:

BACKGROUND: Copolymers of ε-caprolactone and D, L-lactide (PCDLA) has been studied intensely for their good mechanical properties, biodegradability and biocompatibility. However, the study on non-isothermal crystallization kinetics of PCDLA has attracted less attention.
OBJECTIVE: To investigate the non-isothermal crystallization kinetics of PCDLA.
METHODS: PCDLA with a CL/DLLA molar ratio of 90:10 was prepared by ring-opening polymerization and differential scanning calorimetry was employed to study the non-isothermal crystallization kinetics of PCDLA. The kinetics parameters were analyzed by Avrami, Jeziorny and Mo methods.
RESULTS AND CONCLUSION: The crystallization peak temperatures of PCDLA decreased with increasing cooling rate. In the process of non-isothermal crystallization, the value of Avrami index was greater than 3 for PCDLA, which demonstrates a three-dimensional spherulitic growth on homogeneous nuclei. The Jeziorny method of the corrected Avrami theories and Mo method can describe non-isothermal crystallization kinetics of PCDLA very well.

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