Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (18): 3333-3336.doi: 10.3969/j.issn.1673-8225.2012.18.023

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Expression of suppressor of cytokine signaling in villus and decidua tissue of recurrent spontaneous abortion and normal pregnancy: Changing Th1/Th2 balance can influence the outcome of pregnancy  

Lü Xing-yu, Ai Hai-quan, Cai Xia, Li Xiao-lan   

  1. Reproductive Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi　830054, Xinjiang Uygur Autonomous Region, China
  • Received:2011-10-15 Revised:2011-12-29 Online:2012-04-29 Published:2012-04-29
  • Contact: Cai Xia, Doctor, Chief physician, Professor, Doctoral supervisor, Reproductive Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi　830054, Xinjiang Uygur Autonomous Region, China
  • About author:Lü xing-yu★, Studying for master’s degree, Attending physician, Reproductive Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi　830054, Xinjiang Uygur Autonomous Region, China Lxyy323@163.com

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Abstract:

BACKGROUND: Suppressor of cytokine signaling (SOCS) has involved in the regulation of signaling pathways of many cytokines, SOCS1-3 are more prominent in the regulation of pregnancy.
OBJECTIVE: To detect the different expression of SOCS3 protein in villus and decidua tissue of normal early pregnancy and recurrent spontaneous abortion patients.
METHODS: The protein expression of SOCS3 in villus and decidua tissue of normal early pregnancy and recurrent spontaneous abortion patients was detected by Westen blotting.
RESULTS AND CONCLUSION: Compared with normal early pregnancy group, the protein expression of SOCS3 in villus      (P < 0.05) and decidua tissue (P < 0.01) was significantly decreased in recurrent spontaneous abortion group. SOCS3 protein might influence the outcome of the pregnancy. The decreased expression of SOCS3 might lead to the decrease of Th2 reaction and then the abortion. 

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