Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (18): 3329-3332.doi: 10.3969/j.issn.1673-8225.2012.18.022

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Influence of low-molecular-weight heparin or recombinant hirudin on the survival of ear venous congested skin flap of rabbits 

Wang Chun-yan1, Tong Ting-hui2, Han Yin2, Wang Tai-ping2, Liao Yi2   

  1. 1Department of Anesthesiology; 2Plastic and Burn Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou  646000, Sichuan Province, China
  • Received:2011-12-16 Revised:2012-01-05 Online:2012-04-29 Published:2012-04-29
  • Contact: Liao Yi, Professor, Chief physician, Plastic and Burn Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China
  • About author:王春艳★，女，1976年生，吉林省长春市人，汉族， 2005年泸州医学院毕业，硕士，主治医师，主要从事生理学和临床麻醉学研究。tongth@163.com

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Abstract:

BACKGROUND: Low-molecular-weight heparin (LH) and recombinant hirudin (RH) can promote blood circulation.
OBJECTIVE: To investigate the effect of local injection of LH or RH on the survival of venous congested skin flap．
METHODS: Twenty-four rabbits were employed to use the 3 cm×6 cm venous congested skin flap model on the back of left ear. The models were randomly divided into three groups: the control group was performed with multi-point injection of saline under skin flap; LH group was performed with multi-point injection of 625 U/mL LH under skin flap; RH group was multi-point injected with 1 U/mL RH under skin flap.
RESULTS AND CONCLUSION: ① General observation showed that the congestion in RH group and LH group was lighter than that in control group, and the hematoma dissipate quickly in RH group and LH group. ② The percentage of flap survival area in RH group and LH group was higher than that in the control group obviously (P < 0.01), there was no significant difference between RH group and LH group (P > 0.05). ③ Hematoxylin-eosin staining showed that congestion of microvascular in control group after operation was more serious than that in the RH group and LH group (P < 0.05, P < 0.01), the number of microvascular in RH group was higher than that in the LH group (P < 0.01). Local application of LH and RH can improve the congestion of skin flap, inhibit the survival rate of flap. There was better effect of using RH than LH. 

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