Abstract:

BACKGROUND: Biomedical fibrin glue can prevent wound effusion, exudation and adhesion, as well as promote wound healing.
OBJECTIVE: To evaluate the clinical effects of biomedical fibrin glue in submandibular gland surgery.
METHODS: Fifty-eight cases of submandibular gland excision were randomly divided into experimental group (n=28) and control group (n=30). Biomedical fibrin glue was applied in the operative wound of the experimental group after hemostasis, while the control group was not treated with biomedical fibrin glue.
RESULTS AND CONCLUSION: Biomedical fibrin glue formed a jelly-like material after spraying within 5-10 seconds in the experimental group, and solidified completely in 3-5 minutes. The gel was attached to the wound surface and there were no adverse reactions and dysfunctions in the liver and kidney. The total drainage flow and the drainage flow on the first postoperative day of the experimental group were lower than those of the control group (P < 0.05), as well as the extubation time and time for stitches removal were shorter than those of the control group (P < 0.05). Besides, patients with subjective symptoms and scar adhesion formation in the experimental group were better than those in the control group. These findings suggest that biomedical fibrin glue is safe, effective and reliable in submandibular gland surgery for blocking operative wound surface, hemostasis and promoting healing.