Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 3017-3021.doi: 10.3969/j.issn.1673-8225.2012.16.037

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Components of enamel matrix derivative and cyto-differentiation induction effects: A literature review  

Zou Hui-ru1,2○, Zhang Lan-cheng1, Qin Zong-chang1, Yang Xue-bin2○, Steven Brookes2○   

  1. 1Tianjin Stomatological Hospital, Nankai University, Tianjin  300041, China; 2Department of Oral Biology, Leeds Dental Institute, University of Leeds, Leeds LS2 9LU, UK
  • Received:2011-12-27 Revised:2012-02-18 Online:2012-04-15 Published:2012-04-15
  • Contact: Steven Brookes, Department of Oral Biology, Leeds Dental Institute, University of Leeds, Leeds LS2 9LU, UK
  • About author:Zou Hui-ru☆, Doctor, Tianjin Stomatological Hospital, Nankai University, Tianjin 300041, China zouhuiru@163.com

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Abstract:

BACKGROUND: Enamel matrix derivative is a product derived from pig developing enamel which contains various enamel matrix proteins and derivatives. It is believed to act as a tissue-healing modulator which helps stimulate periodontal regeneration, biomineralization and bone induction.
OBJECTIVE: To summarize the components of enamel matrix derivative and the effects of enamel matrix derivative on cyto-differentiation induction providing a basis for the further usage of enamel matrix derivative in tissue engineering research. 
METHODS: A computer-based online search of Chinese Biomedical Literature Analysis and Retrieval System, CNKI, Wanfang and VIP databases was undertaken for the related Chinese articles dated from January 1997 to December 2011 with the keywords of “enamel matrix derivative/enamel matrix protein, Emdogain®, differentiation”. Meanwhile, PubMed and EBSCO HOST databases were searched for the related English articles dated from January 1997 to December 2011 with the same keywords in English. In addition, Chemical Abstracts and Excerpta Medica were manually searched. Those experimental studies involving randomized, blind and controlled condition and observations, comparisons, academic summarization and case reports with no limitations were included. Those with unrelated research subjects, or repetitive studies were excluded. All articles were refined and finally 38 articles were remained for further analysis.
RESULTS AND CONCLUSION: Enamel matrix derivative is the product derived from pig developing enamel which contains various enamel matrix proteins and growth factor-like materials. It is believed to act as a tissue-healing modulator which inhibits or stimulates differentiation of various stem cells. It suggests that enamel matrix derivative can be used not only in periodontal regeneration, but also in other tissue engineering fields.

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