Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 3013-3016.doi: 10.3969/j.issn.1673-8225.2012.16.036

Previous Articles     Next Articles

Application of fibrin glue in orthopedics 

Zhang Fei, Gao Hui   

  1. Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
  • Received:2011-07-20 Revised:2011-08-08 Online:2012-04-15 Published:2012-04-15
  • Contact: Gao Hui, Doctor, Chief physician, Professor, Master’s supervisor, Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China
  • About author:Zhang Fei★, Master, Physician, Department of Orthopedics, First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi Province, China xinfengzhangfei@ 163.com

PDF

483

Abstract:

BACKGROUND: Fibrin glue (FG) is a fibrin preparation, which is composed by fibrinogen, thrombin and other biological activity, and it has various functions such as hemostasia, chemotaxis, promoting cell mitosis and other features, besides, it also has good biocompatibility.
OBJECTIVE: To review the application of FG in orthopedics.
METHODS: The PubMed, Biosis Preview, ScienceDirect, Wanfang and VIP databases were searched by using the keywords of “fibrin glue, biomaterial, application” in English and “fibrin glue, orthopedics, application” in Chinese for relevant articles addressing application of FG in orthopedics published 1995-01/2011-05. Finally, 30 articles were summarized.
RESULTS AND CONCLUSION: FG is a kind of multi-bioactive fibrin, which can rapidly form three-dimensional network structure and play a good hemostatic effect. FG can form a local loop at the injection site to play a closed and adhesive effect, and it can be used for preventing postoperative epidural adhesions, inhibiting local inflammation, reducing swelling pressure, and promoting postoperative wound healing. FG can act as a biological matrix used in bone or cartilage tissue engineering.

CLC Number: