Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (16): 3009-3012.doi: 10.3969/j.issn.1673-8225.2012.16.035

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Application of gamma-poly glutamic acid and its derivatives in biomedical field

Shu Xiu-lin1, Shi Qing-shan1, Huang Xiao-mo2, Zheng Guo-ai2, Ouyang You-sheng1, Chen Yi-ben1   

  1. 1Guangdong Institute of Microbiology, Key Laboratory of Microbial Culture Collection and Application of Guangdong Province, Public Laboratory of Microbial Application of New Technology of Guangdong Province, State Key Laboratory of Applied Microbiology in South China of Guangdong Province (Ministry-Guangdong Province Jointly Breeding Base), Guangzhou  510070, Guangdong Province, China;    2Guangdong Demay Biological Technology Co., Ltd., Guangzhou  510663, Guangdong Province, China
  • Received:2011-09-30 Revised:2011-10-11 Online:2012-04-15 Published:2012-04-15
  • Contact: Shi Qing-shan, Researcher, Guangdong Institute of Microbiology, Key Laboratory of Microbial Culture Collection and Application of Guangdong Province, Public Laboratory of Microbial Application of New Technology of Guangdong Province, State Key Laboratory of Applied Microbiology in South China of Guangdong Province (Ministry-Guangdong Province Jointly Breeding Base), Guangzhou 510070, Guangdong Province, China jigan@gdim.cn
  • About author:Shu Xiu-lin★, Master, Assistant researcher, Guangdong Institute of Microbiology, Key Laboratory of Microbial Culture Collection and Application of Guangdong Province, Public Laboratory of Microbial Application of New Technology of Guangdong Province, State Key Laboratory of Applied Microbiology in South China of Guangdong Province (Ministry-Guangdong Province Jointly Breeding Base), Guangzhou 510070, Guangdong Province, China xiulin5403@126.com
  • Supported by:

    Science and Technology Program of Guangdong Province, No. 2009A010700005*

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Abstract:

BACKGROUND: γ-poly glutamic acid (γ-PGA) is a type of polymer material through fermentation production of microbial bacteria. This polymer has the features of water-solubility, absorbency, moisture retention, biodegradable, no toxicity and safety. The γ-PGA has a wide application prospect in biomedical engineering through composition with other materials.  
OBJECTIVE: To summarize the applications of γ-PGA in drug carriers, wound dressing, cosmetic medicine, and bone tissue engineering.
METHODS: Databases of CNKI, VIP, and Science Direct were retrieved with key words of “γ-poly glutamic acid, drug carrier materials, wound dressing, cosmetic medicine, artificial bone substitute materials” by screening titles and abstracts to search papers published from January 1998 to May 2011. Papers underlying bio-medical were selected. Totally 206 literatures were obtained in initial search, 26 of them were chosen to summarize according to inclusion criteria.
RESULTS AND CONCLUSION: As drug carrier, γ-PGA and its derivatives can improve the water-solubility, reduce the toxicity, and control the release and increase the targeting of drugs. It is an excellent and safe hydrophilic humectant in cosmetic medicine. As wound dressing, the addition of γ-PGA into wound dressing materials leads to a reduction in platelet adhesion and activation to increase hemostatic effect, induce cellular proliferation and differentiation, and improve the stability and effusion absorption of wound dressing. As bone tissue engineering scaffolds, γ-PGA copolymer scaffolds can promote the growth and proliferation of the osteoblasts, exhibit excellent biodegradation and biocompatibility, and are potential in tissue engineering as temporary substitutes for articular cartilage regeneration.

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