Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (14): 2652-2655.doi: 10.3969/j.issn.1673-8225.2012.14.038

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Transplantation of umbilical cord mesenchymal stem cells for treatment of autosomal dominant spinocerebellar ataxias in 12 cases**

Qiu Yun1, Wang Zheng1, Lu Hong-she2, Xu Peng2, Chen Wen-yi2, Lu Yan-guang2, Ding Yong-hong2   

  1. 1Laboratory of Stem Cells, Shanghai Institute of Digestive Disease at Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai  200001, China; 2Center of Stem Cells Transplantation, the 455 Hospital of Chinese PLA, Shanghai  200052, China
  • Received:2011-09-07 Revised:2011-09-15 Online:2012-04-01 Published:2012-04-01
  • Contact: Wang Zheng, Doctor, Associate professor, Laboratory of Stem Cells, Shanghai Institute of Digestive Disease at Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China zheng.w.dr@gmail.com
  • About author:Qiu Yun★, Studying for master’s degree, Laboratory of Stem Cells, Shanghai Institute of Digestive Disease at Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China qyun200911@yahoo.cn
  • Supported by:

    Pujiang Talents Plan of Shanghai Municipal Science and Technology Committee, No. 09PJ1407300*; the National Natural Science Foundation of China, No.30971468*

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Abstract:

BACKGROUND: There is no study addressing transplantation of umbilical cord mesenchymal stem cells for the treatment of spinocerebellar ataxia.
OBJECTIVE: To study the clinical effect of human umbilical cord stem cells transplantation in the treatment of autosomal dominant spinocerebellar ataxias.
METHODS: Spinocerebellar ataxias patients selected from Stem Transplantation Center of the 455 Hospital of Chinese PLA were treated with umbilical cord mesenchymal stem cells transplantation via intrathecal injection. The number of umbilical cord mesenchymal stem cells was 107 per transplantation, once per week, for 4 weeks.
RESULTS AND CONCLUSION: Both the total score of the International Cooperative Ataxia Rating Scale and Activities of Daily Living score were significantly decreased at 1 month after transplantation compared with before treatment (P < 0.05). The nerve function was significantly improved and the total effective rate was up to 16.7%. Experimental findings indicate that, transplantation of umbilical cord mesenchymal stem cells via intrathecal injection is a feasible and effective treatment to ameliorate the clinical efficacy of spinocerebellar ataxias patients and improve their quality of life.

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