Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (47): 8847-8850.doi: 10.3969/j.issn.1673-8225.2011.47.026

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Determination of entrapment efficiency of albendazole chitosan nanoparticles

Lian Wen-yuan1, He Cheng-hui2, Xing Jian-guo2, Wang Xin-chun1,3, Huang Chuan-sheng3   

  1. 1School of Pharmacy, Shihezi University, Shihezi  832000, Xinjiang Uygur Autonomous Region, China
    2Xinjiang Institute of Materia Medica, Urumqi  830004, Xinjiang Uygur Autonomous Region, China
    3the First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832008, Xinjiang Uygur Autonomous Region, China
  • Received:2011-05-27 Revised:2011-08-03 Online:2011-11-19 Published:2011-11-19
  • Contact: Wang Xin-chun, Doctor, Chief pharmacist, Master’s supervisor, School of Pharmacy, Shihezi University, Shihezi 832000, Xinjiang Uygur Autonomous Region, China; the First Affiliated Hospital of Medical College, Shihezi University, Shihezi 832008, Xinjiang Uygur Autonomous Region, China cwjwxc@163.com
  • About author:Lian Wen-yuan★, Studying for master’s degree, School of Pharmacy, Shihezi University, Shihezi 832000, Xinjiang Uygur Autonomous Region, China
  • Supported by:

    the Youth Special Fund of Xinjiang Uygur Autonomous Region, No. 2009211B36*

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Abstract:

BACKGROUND: In the course of studying nanoparticles, the entrapment efficiency is a very important index of nanoparticle quality evaluation.
OBJECTIVE: To establish a method for determination of the entrapment efficiency of albendazole chitosan nanoparticles.
METHODS: Reverse dialysis method was used to determine the entrapment efficiency of albendazole chitosan nanoparticles by analyzing the amount of albendazole with ultraviolet spectrophotometry.
RESULTS AND CONCLUSION: The reverse dialysis method could separate albendazole chitosan nanoparticles from free albendazole, its equilibrium time and the dialyzed volume ratio was 9 hours and 1:15, respectively. The sample recovery rate was (99.59±0.36)%. The average entrapment efficiency of albendazole chitosan nanoparticles was (51.73±0.18)%. Reverse dialysis method was convenient and accurate. It was suitable for determining the entrapment efficiency of albendazole chitosan nanoparticles.

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