Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (47): 8851-8854.doi: 10.3969/j.issn.1673-8225.2011.47.027

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Effect of surface properties of modified hydroxyapatite on the adherent growth of osteoblasts

Wei Jun-chao1, Chen Lei2, Chen Yi-wang1, Chen Xue-si2   

  1. 1Department of Chemistry, Nanchang University, Nanchang  330031, Jiangxi Province, China
    2Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun  130022, Jilin Province, China
  • Received:2011-09-07 Revised:2011-10-08 Online:2011-11-19 Published:2011-11-19
  • Contact: Chen Yi-wang, Doctor, Professor, Department of Chemistry, Nanchang University, Nanchang 330031, Jiangxi Province, China ywchen@ncu.edu.cn
  • About author:Wei Jun-chao☆, Doctor, Lecturer, Department of Chemistry, Nanchang University, Nanchang 330031, Jiangxi Province, China

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Abstract:

BACKGROUND: The alteration of biomaterial surface properties may affect interaction between the biomaterials and cells, which will elicit diverse cell behaviors, such as cell adhesion, gene expression and so on.
OBJECTIVE: To investigate the effects of surface properties of a new type of polymer modified hydroxyapatite (HA) and to determine its effects on adhesion ability of osteoblasts.
METHODS: HA and modified HA were prepared according to author’s previous experiments. The zeta potential of modified HA was measured by using zeta potential analyzer. The water contact angle and cell attachment test were carried out to investigate the effect of surface modification on the cell adhesion ability and the biocompatibility of modified HA.
RESULTS AND CONCLUSION: The surface of modified HA was hydrophobic, and its water contact angle was 93°. Cell attachment test showed that the number of osteoblasts attached on the modified HA surface was higher than that on the HA surface. It is indicated that the surface modification enhances the biocompatibility of HA.

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