Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (15): 2773-2776.doi: 10.3969/j.issn.1673-8225.2011.15.027

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Expression of insulin-like growth factor 1 and inducible nitric-oxide synthase in Vδ1T cells from ischemic diabtetic foot ulcer skins

Xie Cui-song1, 2, Xue Yao-ming1   

  1. 1Department of Endocrinology, Nanfang Hospital of Southern Medical University, Guangzhou  510515, Guangdong Province, China
    2Department of Endocrinology, First People’s Hospital of Chenzhou, Chenzhou  423000, Hunan Province, China
  • Received:2010-12-21 Revised:2011-02-19 Online:2011-04-09 Published:2013-11-06
  • Contact: Xue Yao-ming, Doctor, Chief physician, Professor, Doctoral supervisor, Department of Endocrinology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, Guangdong Province, China xie_h_r@yahoo.com.cn
  • About author:Xie Cui-song☆, Doctor, Attending physician, Department of Endocrinology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, Guangdong Province, China; Department of Endocrinology, First People’s Hospital of Chenzhou, Chenzhou 423000, Hunan Province, China

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Abstract:

BACKGROUND: Skin Vδ1T cells can secrete a series of cell factors that can promote wound healing, but the association between cell factors and nonunion in ischemic diabetic foot ulcer skin are rare reported.
OBJECTIVE: To explore the association of expression of insulin-like growth factor-1 (IGF-1) and inducible nitric-oxide synthase (iNOS) in Vδ1T cells in ischemic diabetic foot ulcer skin.
METHODS: Ten patients with ischemic diabetic foot ulcer and 10 healthy people were selected. The protein expression of IGF-1 and iNOS was detected by Double-2 labeling immunofluorescence.
RESULTS AND CONCLUSION: The protein expression of IGF-1 in Vδ1T cells was decreased in diabetic foot group than that of control group (P < 0.01), but iNOS was increased than that of control group (P < 0.01), which indicated that the decrease of IGF-1 and the increase of iNOS in Vδ1 T cells correlated with ischemic diabetic foot ulcer healing.

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