Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (50): 9471-.doi: 10.3969/j.issn.1673-8225.2010.50.039

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Interleukin-8-251 genetic polymorphisms and susceptibility of gastric cancer among Asians: A Meta-analysis

Li Guang-hui1, Liu Liu2, Liu Hao1, Liu Xi1, Liu Jin1, Ma Li-tai1   

  1. 1 Department of Orthopedics, 2 Department of Gastrointestinal Surgery, West China Hospital of Sichuan University, Chengdu  610041, Sichuan Province, China
  • Online:2010-12-10 Published:2010-12-10
  • Contact: Liu Hao, Doctoral supervisor, Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China liuhao6204@163. com
  • About author:Li Guang-hui★, Studying for master’s degree, Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China skykisssea@163.com

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Abstract:

BACKGROUND: Inflammatory factors play an important role in gastric cancer. Interleukin 8 (IL-8) can be found in many tumor tissues. 
OBJECTIVE: To quantitative analyze the relationship between IL-8-251 genetic polymorphisms and susceptibility of gastric cancer.
METHODS: Medline, Embase and CNKI databases were searched and 9 case-control studies among Asians were included. Stata 10.0 software was used to quantitatively analyze the relationship between IL-8 genetic polymorphisms and risk of gastric cancer. At the same time, stratified analysis was made according to participants from different areas of Asian countries.
RESULTS AND CONCLUSION: The combined OR and 95% CI for IL-8-251 TT genotype and A carrier genotype (AA+AT) among non-Chinese Asians were [0.83, 0.71-0.96] and [1.13, 1.00-1.28], they reached statistical significance. The combined OR and 95% CI for IL-8-251 AA genotype and T carrier genotype (AA+AT) among Asians were [1.15, 0.91-1.45] and [0.99, 0.90-1.07], they did not reach statistical significance. The combined OR and 95% CI for IL-8-251 TT genotype and A carrier genotype (AA+AT) among Chinese were [1.02, 0.85-1.22] and [1.00, 0.87-1.15], they did not reach statistical significance. IL-8-251 genetic polymorphisms might be correlated with susceptibility of gastric cancer among non-Chinese Asians. Non-Chinese Asians with A carrier genotype (AA+AT) might be at high risk of gastric cancer development. In contrast, non-Chinese Asians with TT genotype might be at low risk of gastric cancer development.

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