Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (50): 9431-.doi: 10.3969/j.issn.1673-8225.2010.50.037

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Association between the rs1787997 polymorphism in FECH gene and motion sensitivity in men of Han nationality in northern China

Xu Ya-li1, Hu Yang2, Ren Zhi-jun3, Wen Hui4   

  1. 1 Physical Education College of Henan University, Kaifeng  475001, Henan Province, China; 2 Scientific Research Center, Beijing Sport University, Beijing  100084, China; 3 Department of Hematology, the People’s Hospital of Jiangmen, Jiangmen  529000, Guangdong Province, China; 4 Department of Neurosurgery, Luoyang Central Hospital, Luoyang  471000, Henan Province, China
  • Online:2010-12-10 Published:2010-12-10
  • About author:Xu Ya-li☆ Doctor, Associate professor, Physical Education College of Henan University, Kaifeng 475001, Henan Province, China lanxin1979@163.com
  • Supported by:

    the Foundation of Ministry of Science and Technology of China, No. 2003BA904B04*

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Abstract:

BACKGROUND: There is association between gene polymorphism, motor ability and training sensitivity. Ferrochelatase (FECH) is an enzyme that catalyses the terminal step in the biosynthesis of heme, which has been shown to interact with aerobic performance.
OBJECTIVE: To investigate association of rs1787997 polymorphism of FECH gene and motion sensitivity in men of Han nationality in northern China, and to explore a molecular marker in predicting endurance training response.
METHODS: Totally 102 healthy young male soldiers of Han nationality in northern China were recruited to undergo 18-week    5 000-m running with the intensity of 95%-105% anaerobic threshold, 3 times a week. The running economy was measured before and after the protocol. The PCR-RFLP and gene sequencing was used to analyze the distribution of this polymorphism. The association of the polymorphism with initial endurance capacity and endurance training response was analyzed.
RESULTS AND CONCLUSION: After 18-week 5 000-m running, the decreased degree of ventilation at RE in CC genetype was higher than GG and CG genetypes significantly (P < 0.05). In the rs1787997 polymorphism of FECH gene, CC genetype has higher training response in running economy and might be the genetic marker in predicting endurance training response.

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