Abstract:

BACKGROUND: Support-motion system (skeleton-muscular system) alters during idiopathic scoliosis advancement. Some symptoms present with idiopathic scoliosis, others exhibit secondary scoliosis.
OBJECTIVE: To explore the relationship between pathological change features and etiology of the nucleus scoliosis in patients with scoliosis.
METHODS: Totaly 214 main and compensatory curve samples of nucleus pulposus were harvested from 22 cases with King Ⅱ, Ⅲ types scoliosis, aged 13-15 years, including 3 males and 19 females. After conventional treatment, samples were performed epoxy-polymerization in the isinglass tube. Gelatin blocks were prepared 1 750 copies of a continuous ultra-thin tissue sections. The change features and histochemistrical alteration of nucleus pulpous were observed under an electron microscope.
RESULTS AND CONCLUSION: Under an electron microscope, few fibrous tissue bands could be seen at the junction of plate and nucleus of hyaline cartilage, especially obviously in patients with king Ⅲ type of scoliosis. There were metachromasia non-substances acid mucopolysaccharide and elastin in in the nucleus pulposus cells, but it could not be confirmed resulting from hyaluronic acid (testis hyaluronic acid and bacteria) damage. Electric-chemistry observation showed that, compensatory bend vertex in the cartilage cells presented with nucleus unity, and few lysosomal solution containing lysosomal acid phosphatase could be seen. Dissolved body in these cells were clearly, but lack of internal structures. They were identified as idiopathic structural scoliosis, which not involved in cell self-consuming of dissolution or dissolution of other types of organizations. The various types of cells increased by exogenous brought a large number of lysosomal enzymes, and led to cell autologous consumption, the internal structure of the dissolution, but this destruction process in compensatory bend in the nucleus pulposus has not been found in. Accordingly, in the pathological process of reconstructing nucleus pulposus, lysosomal enzyme paticipates with the form of self-consuming, the ultrastructure of nucleus pulposus was damaged under condition of enzymatic action, thus, result in malformation.