Abstract:

BACKGROUND: Drynaria fortunei can enhance osteoblast activity, elevate bone mineral density, and maintain bone microarchitecture.
OBJECTIVE: To observe the effects of different compositions of drynaria fortunei on bone healing.
METHODS: Totally 30 male Wistar rats were established for femoral shaft defect models and treated by intragastric administration of drynaria fortune extraction and hesperidin (20 g/kg). The bone healing and hemorheology indexes were detected at 21 days after treatment. 
RESULTS AND CONCLUSION: The different compositions of drynaria fortunei were all beneficial to the bone healing, especially total flavonoid, which showed better results than naringin and hesperidin (P < 0.05). The drynaria fortunei total flavonoid could inhibit effectively the blood viscosity of the rats in speed of lower shearing, and repress notably the index number of aggregation of the red cells. In addition, it also could suppress notably platelet aggregation, and reduce platelet adhesion. The findings demonstrated that, drynaria fortune, especially total flavonoid, can be propitious to the bone healing, which has function to the hemorheology of rats.