Chinese Journal of Tissue Engineering Research ›› 2010, Vol. 14 ›› Issue (37): 6938-6942.doi: 10.3969/j.issn.1673-8225.2010.37.023

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Pharmacokinetic features of Danshensu in rat main tissues

Zhou Lu-yi1, Lu Cheng-yu2   

  1. 1 Department of Laboratory Management, 2 Department of Pharmacology, College of Pharmacy, Guangdong Medical College, Dongguan  523808, Guangdong Province, China
  • Online:2010-09-10 Published:2010-09-10
  • About author:Zhou Lu-yi★, Master, Department of Laboratory Management, Guangdong Medical College, Dongguan 523808, Guangdong Province, China zly820601@163.com
  • Supported by:

     the Natural Science Foundation of Guangdong Province, No. KZ0701*

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Abstract:

BACKGROUND: The in vivo pharmacokinetic features of Danshensu have been reported, but there are few studies concerning the distribution of Danshensu in rat main tissues.
OBJECTIVE: To study the distribution and pharmacokinetics of Danshensu in rat main tissues following intravenous injection of compound Danshen solution.
METHODS: Liquid-liquid extraction was used to deal with the serum and main tissues (kidney, spleen, heart, liver, lung, abdomen and back skins, as well as bone tissues). The conditions for HPLC were: 4-hydroxy-benzoic acid served as the internal standard, the CH3OH-1%CH3COOH (8:92) served as mobile phase, and detection wavelength was 280 nm. 
RESULTS AND CONCLUSION: Except the brains, Danshensu could find in the rat serum and the main tissues after intravenous injection of compound Danshen solution. The column of serum concentration-time and tissues concentration-time was drew using the established methods. The results demonstrated that except the brains, Danshensu could distribute rapidly in main tissues after intravenous injection of compound Danshen solution, and the pharmacokinetics fitted to two-compartment model.

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