Abstract:

OBJECTIVE: To explore effects and safety of immunosuppressive agent on acute rejection following renal transplantation.
METHODS: We retrieved Vip and Tsinghua Tongfang Databases for relevant articles published from January 2000 to October 2009. The key words were “renal transplantation, immunosuppressive agent, mycophenolate, tacrolimus, cyclosporine, rapamycin, anti-CD25 monoclonal antibody, anti-CD3 monoclonal antibody”. The contents should be associated with the study concerning prevention and treatment of immunosuppressive agent on acute rejection following renal transplantation.
RESULTS: The use of immunosuppressive agent for renal transplantation can decrease the incidence rate of acute rejection, which can significantly improve the survival of transplanted kidney in a short period. However, the renal toxicity of immunosuppressive agent remains a key factor for restricting long-term survival of the transplanted kidney. Recently, novel immunosuppressive agents enable the long-term survival of transplanted kidney such as rapamycin and FFY720. Novel immunosuppressive agents should pay great attention on reducing adverse reactions, rather than the reduction in incidence rate of rejection alone.
CONCLUSION: With the deep understanding of transplantation immunity, we have made great progresses in immunosuppressive agents, which provide more and more choices for clinical physicians. However, satisfactory immunosuppressive agents and schemes deserve further investigations.