Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (28): 4492-4497.doi: 10.3969/j.issn.2095-4344.2310
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Wang Le, Hui Min, Dong Xiling, Zhou Han, Dong Hongliang, Zhang Xiaoming, Liu Tongbin
Department of Prosthodontics, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
Received:
2019-12-02
Revised:
2019-12-05
Accepted:
2020-01-02
Online:
2020-10-08
Published:
2020-08-31
Contact:
Zhang Xiaoming, Master, Chief physician, Master’s supervisor, Department of Prosthodontics, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
Liu Tongbin, Master, Department of Prosthodontics, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
About author:
Wang Le, Master candidate, Department of Prosthodontics, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China
Supported by:
the Medical and Health Science and Technology Development Plan Project of Shandong Province, No. 2016WS0121; the Science and Technology Program of Binzhou Medical University, No. BY2017KJ05
CLC Number:
Wang Le, Hui Min, Dong Xiling, Zhou Han, Dong Hongliang, Zhang Xiaoming, Liu Tongbin. Effects of sustained-release atorvastatin calcium nanofiber scaffold on cell adhesion and proliferation[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(28): 4492-4497.
2.3 缓释阿托伐他汀钙纤维膜的失重率 聚己内酯作为高分子聚合物其分子链中具有众多酯键,酯键发生断裂会导致高分子材料整体结构破坏,导致分子质量下降。缓释阿托伐他汀钙纤维膜1,2,3个月时的失重率分别为18.33%,29.54%,35.70%。第1个月时材料降解速度是最快的,后期降解速度减缓,这是因为高分子聚合物包含的酯键水解断裂是随意的,降解初期链包含酯键分子位点多。降解1个月时,明显感觉材料变得松软,机械性能下降,但是尚可成膜,降解3个月时材料已经不完整。 2.4 缓释阿托伐他汀钙纳米纤维支架的药物释放 药物包封率70%左右,大部分药物可以包裹在牛血清白蛋白微球中。药物缓释支架前期释放较快,前3 d已达21%,体现了短期的爆发式的释放规律,后期释放逐渐变慢,3-30 d的释放模式类似药物零级释放动力学。药物缓释支架持续释放药物时间可达1个月以上,累计释放量达63%,1个月以后药物仍然缓慢释放,见图5。多重屏障半衰期明显延长,整体分为2个阶段,前期短暂的突释放可迅速使药物达到有效作用浓度,后期的缓慢释放可维持药物浓度并明显延长药物作用时间。 "
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