Effect of kidney-tonifying recipe on tendon-bone healing after anterior cruciate ligament reconstruction

doi:10.3969/j.issn.2095-4344.2017.04.017

Abstract

Abstract:

Abstract
BACKGROUND: Kidney-tonifying herbs have been reported to promote tendon-bone healing in rabbits after anterior cruciate ligament reconstruction (ACLR).
OBJECTIVE: To verify the effects of kidney-tonifying herbs on tendon-bone healing after ACLR.
METHODS: Seventy patients with anterior cruciate ligament injury undergoing ACLR were randomly assigned to study group (administration of Liuwei dihuang pills+celecoxib) and control group (administration of celecoxib alone). Preoperative, postoperative 6- and 12-month assessments of patients by the Lysholm Knee Scoring Scale, International Knee Documentation Committee (IKDC) Subjective Knee Form and MRI imaging were performed.
RESULTS AND CONCLUSION: Postoperative Lysholm scores were significantly increased compared with preoperation in the study and control groups (P < 0.05), and the scores of sections stair-climbing and instability and total scores of the Lysholm Knee Scoring Scale in the study group were superior to those in the control group (P < 0.05). Postoperative IKDC scores were significantly increased compared with pre-operation in the study and control groups (P < 0.05), and the scores of section flaccid leg and subjective function and total scores of the IKDC in the study group were superior to the control group (P < 0.05). The enlargement rate of middle and proximal parts of grafts was significantly increased in the study group compared with the control group 6 months postoperatively (P < 0.05), and the enlargement rate of middle and distal parts of grafts was significantly increased in the study group compared with the control group 12 months postoperatively (P < 0.05). The tibial and femoral tunnel enlargement was observed in both groups at 6 and 12 months postoperatively (P < 0.05). The enlargement rate of the tibial tunnel was significantly decreased in the study group compared with in the control group (P < 0.05). The signal-noise ratio of the femoral end and middle part of grafts in the study group was significantly higher than that in the control group 6 months postoperatively (P < 0.01). In contrast, the signal-noise ratio of the femoral end and middle part of grafts in the study group was significantly lower than that in the control group 12 months postoperatively (P < 0.05). Our results indicate that kidney-tonifying herbs can improve the tendon-bone healing after ACLR.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Anterior Cruciate Ligament, Drugs, Chinese Herbal, Transplants

CLC Number:

R318

Yang Wei-yi, Pan Jian-ke, Xie Hui, Zhang Zhi-mian, Cao Xue-wei, Liu Jun. Effect of kidney-tonifying recipe on tendon-bone healing after anterior cruciate ligament reconstruction[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(4): 591-597.

Figures/Tables 4

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