Association between low bone mineral density and Gensini integral in patients with coronary artery disease

doi:10.3969/j.issn.2095-4344.2015.51.003

Abstract

Abstract:

BACKGROUND: Studies have shown that coronary heart disease and osteoporosis have the same pathophysiology mechaism, and atherosclerosis is evidently correlated with osteoporosis.
OBJECTIVE: To study the relationship between the severity of coronary lesions and osteoporosis in patients with coronary heart disease.
METHODS: Totally 322 in-hospital patients diagnosed as having coronary artery disease by coronary angiography were retrospectively selected and divided into osteoporosis group and non-osteoporosis group. Multiple linear regression model was used to analyze the correlation between osteoporosis and Gensini score indicating the severity of coronary lesion.
RESULTS AND CONCLUSION: Patients in the osteoporosis group had fewer coronary single branch lesions (P < 0.001), more coronary multivessel lesions (P < 0.001) and higher Gensini score (P < 0.001) compared with those in the non-osteoporosis group. Multivariate linear regression analysis showed osteoporosis was a risk factor of Gensini score (P < 0.001) after adjustment for possible factors. Correlation analysis showed that bone mineral density and Gensini score were negatively correlated (r=-0.36, P=0.004). These findings indicate that osteoporosis is closely related to the severity of coronary artery disease.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

CLC Number:

R318

Fan Shan, An Yuan-yuan, Zhou Yun, Chen You, Ma Yan. Association between low bone mineral density and Gensini integral in patients with coronary artery disease[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(51): 8213-8217.

Figures/Tables 4

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