Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (27): 4394-4399.doi: 10.3969/j.issn.2095-4344.2015.27.024

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Constructing muscle-relaxation rabbit models by continuous infusion of propofolin in the internal carotid artery: pharmacokinetic variations

Yin Hong1, Tan Yuan1, Tang Zhi-yin1, Xiang Rong-wu2, Zhu Jun-chao1   

  1. 1Second Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China; 
    2Department of Mathematics, Shenyang Pharmaceutical University, Shenyang 110001, Liaoning Province, China
  • Online:2015-06-30 Published:2015-06-30
  • Contact: Zhu Jun-chao, M.D., Master's supervisor, Second Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
  • About author:Yin Hong, M.D., Second Department of Anesthesiology，Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 81071449

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Abstract:

BACKGROUND: Intracerebral administration of selective drugs via the carotid artery is currently one of the effective methods to enhance the drug concentration in the brain and reduce the influence of drugs on other system functions.
OBJECTIVE: To establish the muscle-relaxation rabbit models by infusing propofol continuously in the internal carotid artery and analyze the variations of propofol concentration.
METHODS: The muscle-relaxation rabbit models were established by continuously infusing propofol at a constant speed via catheterization in the internal carotid artery. The pharmacokinetic characteristics could be analyzed by the methods of obtaining arterial and venous blood on both sides of neck and samples of brain tissue on both sides in different points, detecting drug concentration using high pressure liquid assay, and then mathematically conversing the resulting data for fitting processing and statistical regression.
RESULTS AND CONCLUSION: The method of determining the concentration of propofol using high pressure liquid assay is feasible, stable and reliable. Through investigating the concentration of propofol infused via the carotid artery at different time points, we discovered that the growth rate distribution of propofol concentration and  data distribution are in log-normal distribution profile which belong to non-exponential kinetics model, i.e., modified log-normal distribution model,                  , where σ is the range of drug concentration growth indicating stability of concentration changes, which is an integrated variable related to various factors, such as brain tissue uptake of drugs and brain circulation. The pharmacokinetic model of continuously infusing propofol in the internal carotid artery belongs to log-normal distribution function, i.e., a non-exponential function kinetics model. The brain concentration variations on both sides changing over time follow log-normal distribution function law.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

Key words: Propofol, Muscle Relaxation, Chromatography, High Pressure Liquid, Pharmacokinetics

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