Polypeptide drugs for oral administration with nanoparticles as carriers: current situation, existing problems and developmental prospects

doi:10.3969/j.issn.2095-4344.2015.25.030

Abstract

Abstract:

BACKGROUND: The new formulation and preparation technology of new drugs have become a hot spot for improving the utilization of polypeptides. In particular, the development of nanotechnology in recent years has promoted the clinical application of polypeptide drugs.
OBJECTIVE: To review the current research of nanoparticles as carriers of polypeptide drugs for oral administration.
METHODS: A computer-based search of CNKI database and SCI database was performed for relevant articles published from 1996 to 2014 by using the keywords of “protein, peptide drugs, nanoparticles, oral administration” in Chinese and English, respectively.
RESULTS AND CONCLUSION: The encapsulation efficiency, release rate of drug delivery, stability of nanoparticles in the gastrointestinal tract and penetrability of the intestinal mucosa are determined by many factors, such as the kind, size, surface charge and modification of nanoparticles. The nanoparticles can increase the stability of protein drugs and improve the bioavailability of drugs. The targeting property of the nanoparticles can decrease the adverse reactions of some drugs. The release effect of the nanoparticles can decrease the dosage of drugs and increase the drug circulating time. However, there are still many problems to be solved in nanotechnology: the activities of some protein drugs are lost in the preparation process; theencapsulation efficiency and drug loading need to be improved; protein burst release cannot be solved completely; the mass production of nanoparticles is still difficult.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Peptides, Nanoparticles, Administration, Oral

CLC Number:

R318

Lu Mei-jiao, Fan Hua-ying. Polypeptide drugs for oral administration with nanoparticles as carriers: current situation, existing problems and developmental prospects[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(25): 4091-4095.

Figures/Tables 1

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