Post-osteomyelitis posterior tibial bone defects repaired with antibiotic bone cement combined with autologous bone graft and Ilizarov external fixator

doi:10.3969/j.issn.2095-4344.2015.25.002

Abstract

Abstract:

BACKGROUND: Bone cement containing antibiotics for repair of bone defects can achieve sustained release of a higher concentration of sensitive drugs, which will help kill bacteria and provide the necessary bone grafting bed and space to reduce massive bleeding due to removal of the granulation at bone defects during the second phase.
OBJECTIVE: To analyze the clinical efficacy of antibiotic bone cement combined with autologous bone transplantation and Ilizarov external fixator on tibial bone defects after traumatic osteomyelitis.
METHODS: A total of 31 patients with tibial bone defects after chronic osteomyelitis, including 19 males and 12 females, aged 17-40 years old. After positive debridement of necrotic tissues at bone stump, Ilizarov external fixator was used for fracture fixation, and autogenous iliac bone grafting combined with bone cement containing antibiotics was performed to repair bone defects. Fracture healing time, knee and ankle scoring were followed up.
RESULTS AND CONCLUSION: The 31 patients were followed up for 6 months to 3.5 years. Tibial fractures were healed without infection recurrence in all patients. The bony union time was 3-6 months, the fixation time was 3-6 months, and the limb extended length was (7.50±1.01) cm. No adverse reactions related to bone cement and bone graft occurred. At 3 months after bone grafting, the scores on the knee and ankle joints were improve significantly. These findings indicate that the antibiotic bone cement combined with autologous bone transplantation and Ilizarov external fixator for repair of post-osteomyelitis posterior tibial bone defects can control infection, promote fracture healing, and restore joint functions.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Bone Transplantation, Osteomyelitis

CLC Number:

R318

Zhu Yong-gang, Zhang Da-wei, Zhao Guang-yue, Qi Wei, Sun Qiang, Zuo Ji-wei, Yang Yong-li . Post-osteomyelitis posterior tibial bone defects repaired with antibiotic bone cement combined with autologous bone graft and Ilizarov external fixator [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(25): 3942-3946.

Figures/Tables 2

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