Umbilical cord blood stem cell transplantation and endovascular treatment of diabetic lower limb ischemic disease

doi:10.3969/j.issn.2095-4344.2015.23.025

Abstract

Abstract:

BACKGROUND: In recent years, interventional therapy because of its high success rate, good curative effect, little trauma has been widely recognized, but vascular intimal injury due to interventional therapy still has no effective treatment, resulting in long-term postoperative severe restenosis. Stem cell transplantation has brought a new drawn for the repair of impaired endothelial function, reendothelialization and aided restoration of the blood supply to ischemic tissues.
OBJECTIVE: To summarize the recent progress in umbilical cord blood stem cells transplantation and endovascular treatment for treatment of diabetic lower limb ischemic disease.
METHODS: A computer-based search of PubMed and CNKI was performed for relevant articles published from January 2000 to March 2015 using the keywords of “umbilical cord blood stem cell transplantation, percutaneous transluminal angioplasty, diabetic lower limb ischemia, restenosis” in English and Chinese. Totally 216 relevant literatures were initially obtained, and 44 articles were ultimately included.
RESULTS AND CONCLUSION: By comparing the therapeutic efficacy and long-term prognosis of umbilical cord blood stem cell transplantation and endovascular treatment, it is concluded that umbilical cord blood stem cell transplantation combined with endovascular treatment is better than either of them alone, which can promote the establishment of collateral circulation, improve the impaired endothelial function and reduce the occurrence of restenosis after interventional therapy.

中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

Key words: Cord Blood Stem Cell Transplantation, Diabetic Angiopathies, Angioplasty

CLC Number:

R318

Ma Hong-fang, Wang Fu-jun . Umbilical cord blood stem cell transplantation and endovascular treatment of diabetic lower limb ischemic disease [J]. Chinese Journal of Tissue Engineering Research, 2015, 19(23): 3755-3760.

Figures/Tables 1

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