Biovalve and meachanical valve replacement for valvular disease: the value of serum Apelin-12 detection

doi:10.3969/j.issn.2095-4344.2015.16.023

Abstract

Abstract:

BACKGROUND: Artificial valve replacement for valvular disease has good biocompatibility and hemodynamic characteristics, but there are still many factors that affect its therapeutic effects.
OBJECTIVE: To detect the level of serum Apelin-12 in the perioperative period of valve replacement in valvular disease patients with atrial fibrillation.
METHODS: Sixty-two patients with valvular heart disease scheduled for artificial valve replacement were selected, including 30 patients with persistent atrial fibrillation (atrial fibrillation group) and 32 patients with sinus rhythm (sinus rhythm group). There were 33 males and 29 females, with a mean age of (55±11) years. Levels of serum Apelin-12 and makers related to inflammation and oxidative stress were detected in two groups at admission. Furthermore, the sinus rhythm group was sub-divided into postoperative atrial fibrillation (POAF)
group (n=8) and non-POAF group (n=24) after valve replacement, and the above-mentioned indicators were detected and compared between these two subgroups.
RESULTS AND CONCLUSION: Compared with the sinus rhythm group, the serum level of Apelin-12 was significantly lower in the atrial fibrillation group, while the levels of high-sensitivity C-reactive protein and interleukin-6 and total antioxidant capacity were significantly higher in the atrial fibrillation group (P < 0.05). Correlation analysis showed that the serum level of Apelin-12 was negatively correlated with high-sensitivity C-reactive protein level and total antioxidant capacity (r=-0.265, P=0.045; r=-0.960, P < 0.001), but not correlated with the interleukin-6 level (r=-0.155，P=0.230). Compared with the non-POAF group, the serum level of Apelin-12 was significantly lower in the POAF group (P < 0.05), but the left atrial diameter, high-sensitivity C-reactive protein level were higher in the POAF group (P < 0.05). Apelin-12 may take part in the occurrence and maintenance of atrial fibrillation through the regulation of inflammations and oxidative stresses. The testing of serum Apelin-12 has a certain value in predicting the occurrence of postoperative atrial fibrillation.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: Heart Valve Prosthesis, Atrial Fibrillation, Heart Valve Diseases

CLC Number:

R318

Hou Peng, Wang Hui-shan, Han Jin-song. Biovalve and meachanical valve replacement for valvular disease: the value of serum Apelin-12 detection[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(16): 2583-2587.

Figures/Tables 1

References

[1] Chugh SS,Havmoeller R,Narayanan K,et al.Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation.2014;129(8):837-847.
[2] 黄从新,张澍,马长生,等.心房颤动:目前的认识和治疗建议—2012[J].中华心律失常学杂志,2012,16(4):246-289.
[3] Wu N,Xu B,Xiang Y,et al.Association of inflammatory factors with occurrence and recurrence of atrial fibrillation: a meta-analysis.Int J Cardiol.2013;169(1):62-72.
[4] Kumagai K,Nakashima H,Saku K.The HMG-CoA reductase inhibitor atorvastatin prevents atrial fibrillation by inhibiting inflammation in a canine sterile pericarditis model.Cardiovasc Res.2004;62(1):105-111.
[5] Youn JY,Zhang J,Zhang Y,et al.Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase.J Mol Cell Cardiol.2013;62:72-79.
[6] Elahi MM,Flatman S,Matata BM.Tracing the origins of postoperative atrial fibrillation: the concept of oxidative stress-mediated myocardial injury phenomenon.Eur J Cardiovasc Prev Rehabil.2008;15(6):735-741.
[7] Tatemoto K,Hosoya M,Habata Y,et al.Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.Biochem Biophys Res Commun.1998; 251(2):471-476.
[8] Habchi M,Duvillard L,Cottet V,et al.Circulating apelin is increased in patients with type 1 or type 2 diabetes and is associated with better glycaemic control. Clin Endocrinol (Oxf). 2014;81(5):696-701.
[9] Przewlocka-Kosmala M,Kotwica T,Mysiak A,et al.Reduced circulating apelin in essential hypertension and its association with cardiac dysfunction.J Hypertens.2011;29(5):971-979.
[10] Kadoglou NP,Lampropoulos S,Kapelouzou A,et al.Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease- KOZANI STUDY.Transl Res.2010;155(5):238-246.
[11] Pisarenko OI,Lankin VZ,Konovalova GG,et al.Apelin-12 and its structural analog enhance antioxidant defense in experimental myocardial ischemia and reperfusion. Mol Cell Biochem.2014;391(1-2):241-250.
[12] Lim R,Barker G,Riley C,et al.Apelin is decreased with human preterm and term labor and regulates prolabor mediators in human primary amnion cells.Reprod Sci.2013;20(8):957-967.
[13] Pan CS,Teng X,Zhang J,et al.Apelin antagonizes myocardial impairment in sepsis.J Card Fail.2010;16(7):609-617.
[14] Foussal C,Lairez O,Calise D,et al.Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Lett.2010;584(11):2363-2370.
[15] Than A,Zhang X,Leow MK,et al.Apelin attenuates oxidative stress in human adipocytes.J Biol Chem.2014;289(6):3763-3774.
[16] Ellinor PT,Low AF,Macrae CA.Reduced apelin levels in lone atrial fibrillation.Eur Heart J.2006;27(2):222-226.
[17] Falcone C,Buzzi MP,D'Angelo A,et al.Apelin plasma levels predict arrhythmia recurrence in patients with persistent atrial fibrillation.Int J Immunopathol Pharmacol.2010;23(3):917-925.
[18] Wann LS,Curtis AB,Ellenbogen KA,et al.2011 ACCF/AHA/HRS focused update on the management of patients with atrial fibrillation (update on Dabigatran): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2011;123(10):1144-1150.
[19] Ellinor PT,Low A,Patton KK,et al.C-Reactive protein in lone atrial fibrillation.Am J Cardiol.2006;97(9):1346-1350.
[20] Mathew JP,Fontes ML,Tudor IC,et al.A multicenter risk index for atrial fibrillation after cardiac surgery.JAMA. 2004;291(14): 1720-1729.
[21] Osranek M,Fatema K,Qaddoura F,et al.Left atrial volume predicts the risk of atrial fibrillation after cardiac surgery: a prospective study.J Am Coll Cardiol.2006;48(4):779-786.